publication . Article . 2017

Metabonomics-based analysis of Brachyspira pilosicoli's response to tiamulin reveals metabolic activity despite significant growth inhibition

Roberto M. La Ragione; Jade L Passey; Sandrine P. Claus; Caroline Ivanne Le Roy; Martin J. Woodward;
Open Access
  • Published: 01 Jun 2017 Journal: Anaerobe, volume 45, pages 71-77 (issn: 1075-9964, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Pathogenic anaerobes Brachyspira spp. are responsible for an increasing number of Intestinal Spirochaetosis (IS) cases in livestock against which few approved treatments are available. Tiamulin is used to treat swine dysentery caused by Brachyspira spp. and recently has been used to handle avian intestinal spirochaetosis (AIS). The therapeutic dose used in chickens requires further evaluation since cases of bacterial resistance to tiamulin have been reported. In this study, we evaluated the impact of tiamulin at varying concentrations on the metabolism of B. pilosicoli using a 1 H-NMR-based metabonomics approach allowing the capture of the overall bacterial meta...
free text keywords: Microbiology, Infectious Diseases, Antibiotics, medicine.drug_class, medicine, Therapeutic index, Antibiotic resistance, Biology, Brachyspira pilosicoli, biology.organism_classification, Bacteria, Tiamulin, chemistry.chemical_compound, chemistry, Drug resistance, Brachyspira
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