publication . Article . 2013

MIR221/222 PROMOTE VASCULAR CALCIFICATION

Mackenzie, N C W; Staines, K A; Zhu, D; Genever, P; MacRae, V E; Edinburgh; York;
Open Access English
  • Published: 01 Oct 2013 Journal: Cell Biochemistry and Function, volume 32, issue 2, pages 209-216 (issn: 0263-6484, eissn: 1099-0844, Copyright policy)
  • Publisher: Blackwell Publishing Ltd
  • Country: United Kingdom
Abstract
Vascular calcification shares many similarities with skeletal mineralisation and involves the phenotypic trans-differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic cells within a calcified environment. Various microRNAs (miRs) are known to regulate cell differentiation; however, their role in mediating VSMC calcification is not fully understood. miR-microarray analysis revealed the significant down-regulation of a range of miRs following nine days in culture, including miR-199b, miR-29a, miR-221, miR-222 and miR-31 (p<0.05). Subsequent studies investigated the specific role of the miR-221/222 family in VSMC calcification. Real-time quantitativ...
Subjects
free text keywords: Research Articles, calcification, Enpp1, microarray, miRNA, vascular smooth muscle cell, Clinical Biochemistry, Cell Biology, Biochemistry, General Medicine, Biology, Transfection, Cell, medicine.anatomical_structure, medicine, RUNX2, microRNA, medicine.disease, Cellular differentiation, Real-time polymerase chain reaction, Vascular smooth muscle
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publication . Article . 2013

MIR221/222 PROMOTE VASCULAR CALCIFICATION

Mackenzie, N C W; Staines, K A; Zhu, D; Genever, P; MacRae, V E; Edinburgh; York;