Investigation of protein induction in vascular-targeted strategies.

Doctoral thesis English OPEN
Cole, Laura Margaret.
  • Publisher: Sheffield Hallam University,

The aims of the study reported in this thesis were to develop and utilise mass spectrometry imaging techniques (MALDI-MSI), in combination with conventional proteomic methodologies, to investigate protein induction in vascular-targeted strategies. Proteins thought to be... View more
  • References (2)

    Figure 1.1: Percentage of all deaths due to cancer in the different regions of the world (WHO) Regions of the World............................................................................................................................... 19 Figure 1. 2: Cancer incidence worldwide map.....................................................................................20 Figure 1.3 : The 20 Most Common Causes of Cancer Death, UK..................................................... 21 Chapter 3

    MALDI images showing spatial distribution of Plectin at m/z 977................................................. 174 Figure 3. 39: Immunohistochemical staining of Plectin in Fibrosarcoma 188 tissue post CA-4-P treatm ent................................................................................................................................................ 175 Figure 3.40: Optical scans of anti-Plectin and HSP-90 Immunohistochemical staining in fibrosarcoma 188 serial sections, 72h post CA-4-P treatm en t...................................................... 177 Figure 3.41: Example MS/MS spectrum and normalised intensity graph of IQGAP1 in fibrosarcoma 188 LC-ESI-MS/MS results............................................................................................ 178 Figure 3.42: Example MS/MS spectrum and normalised intensity graph of Tenascin C in fibrosarcoma 188 LC-ESI-MS/MS results............................................................................................ 179 Figure 3.43: Example MS/MS spectrum and normalised intensity graph of Alpha-enolase in fibrosarcoma 188 LC-ESI-MS/MS results............................................................................................ 180 Figure 3.44: Example MS/MS spectrum and normalised intensity graph of Transforming growth factor-beta-induced protein ig-h3 (Tgfbi) in fibrosarcoma 188 LC-ESI-MS/MS results.

  • Similar Research Results (3)
  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    53
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    Sheffield Hallam University Research Archive - IRUS-UK 0 53
Share - Bookmark