publication . Article . 2000

Design of the Intravenous Magnesium Efficacy in Acute Stroke (IMAGES) trial

Bradford, A.; Lees, K.;
Open Access English
  • Published: 01 Dec 2000
  • Publisher: Biomed Central
  • Country: United Kingdom
The Intravenous Magnesium Efficacy in Acute Stroke (IMAGES) trial is a multicentre,randomised, placebo-controlled trial of magnesium sulphate (MgSO4) funded by the UK Medical Research Council. When complete, it will be the largest single neuroprotective study undertaken to date. Conscious patients presenting within 12 h of acute stroke with limb weakness are eligible. The primary outcome measure is combined death and disability as measured using the Barthel Index at 90-day follow up. By randomizing 2700 patients, the study will have 84% power to detect a 5.5% absolute reduction in the primary end-point. By April 2000, 86 centres were participating, with represen...
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24 references, page 1 of 2

1. Izumi Y, Roussel S, Pinard E, Seylaz J: Reduction of infarct volume by magnesium after middle cerebral artery occlusion in rats. J Cereb Flow Metab 1991, 11:1025-1030.

2. Marinov MB, Harbaugh KS, Hoopes PJ, Pikus HJ, Harbaugh R: Neuroprotective effects of pre-ischemia intraarterial magnesium sulfate in reversible focal cerebral ischemia. J Neurosurg 1996, 85: 117-124. [OpenAIRE]

3. McDonald JW, Silverstein FS, Johnston MV: Magnesium reduces Nmethyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neuroscience 1990, 109:234-238.

4. Tsuda T, Kogure K, Nishioka K, Watanabe T: Mg2+ administered up to twenty-four hours following reperfusion prevents ischemic damage of the CA1 neurons in the rat hippocampus. Neuroscience 1991, 44:335-341.

5. Chi OZ, Pollak P, Weiss HR: Effects of magnesium sulfate and nifedipine on regional cerebral blood flow during middle cerebral artery ligation in the rat. Arch Int Pharmacodyn Ther 1990, 304:196- 205.

6. Kemp PA, Gardiner SM, Bennett T, Rubin PC: Magnesium sulphate reverses the carotid vasoconstriction caused by endothelin-I, angiotensin II and neuropeptide-Y, but not that caused by NGnitro-L-arginine methyl ester, in conscious rats. Clin Sci 1993, 85: 175-181.

7. Nowak L, Bregestovski P, Ascher P: Magnesium gates glutamateactivated channels in mouse central neurones. Nature 1984, 307: 462-465. [OpenAIRE]

8. Harrison NL, Simmonds MA: Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex. Br J Pharmacol 1985, 84:381-391. [OpenAIRE]

9. Iseri LT, French JH: Magnesium: nature's physiologic calcium blocker. Am Heart J 1984, 108:188-193. [OpenAIRE]

10. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group: ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 1995, 345:669-685.

11. Woods KL, Fletcher S: Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1994, 343:816-819.

12. Lucas MJ, Leveno KJ, Cunningham FG: A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med 1995, 333:201-205. [OpenAIRE]

13. The Eclampsia Trial Collaborative Group: Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet 1995, 345:1455-1463.

14. Thurnau GR, Kemp DB, Jarvis A: Cerebrospinal fluid levels of magnesium in patients with pre-eclampsia after treatment with intravenous magnesium sulfate: a preliminary report. Am J Obstet Gynecol 1987, 157:1435-1438.

15. Muir KW, Lees KR: A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke. Stroke 1995, 26:1183-1188.

24 references, page 1 of 2
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