publication . Article . 2016

Lifting the Differentiation Embargo

Anne-Louise Latif; Tessa L. Holyoake;
Open Access English
  • Published: 22 Sep 2016
  • Publisher: Elsevier (Cell Press)
  • Country: United Kingdom
Abstract
Effective differentiation therapy for acute myeloid leukemia (AML) has been restricted to a small subset of patients with one defined genetic abnormality. Using an unbiased small molecule screen, Sykes et al. now identify a mechanism of de-repression of differentiation in several models of AML driven by distinct genetic drivers.
Subjects
Medical Subject Headings: hemic and lymphatic diseases
free text keywords: Small molecule, Myeloid leukemia, GENETIC ABNORMALITY, Differentiation therapy, Genetics, Biology
Related Organizations

Burnett, A. K. (2012). Treatment of acute myeloid leukemia: are we making progress? Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 2012, 1-6.

Collins, C. T., & Hess, J. L. (2015). Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets. Oncogene, 35(9), 1090- 1098.

Gilliland, D. G & Griffin, J.D. (2002). The roles of FLT3 in hematopoiesis and leukemia. Blood, 100(5), 1532-1542.

Lo-Coco, F., Avvisati, G., Vignetti, M., Thiede, C., Orlando, S. M., Iacobelli, S., et al. (2013). Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia. New England Journal of Medicine, 369(2), 111- 121. [OpenAIRE]

Munier-Lehmann, H., Vidalain, P.-O., Tangy, F., & Janin, Y. L. (2013). On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses. Journal of Medicinal Chemistry, 56(8), 3148-3167. [OpenAIRE]

Papaemmanuil, E., Gerstung, M., Bullinger, L., Gaidzik, V. I., Paschka, P., Roberts, N. D., et al. (2016). Genomic Classification and Prognosis in Acute Myeloid Leukemia. New England Journal of Medicine, 374(23), 2209-2221. [OpenAIRE]

Sanz, M. A., Grimwade, D., Tallman, M. S., LOwenberg, B., Fenaux, P., Estey, E. H., et al. (2009). Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood, 113(9), 1875-1891. [OpenAIRE]

Sykes,D.B., Kfoury, S.Y., Mercier, F.E., Wawer, M.J., et al. (2016). Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukaemia. Cell,

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publication . Article . 2016

Lifting the Differentiation Embargo

Anne-Louise Latif; Tessa L. Holyoake;