Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

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Estrada, Karol; Styrkarsdottir, Unnur; Evangelou, Evangelos; Hsu, Yi-Hsiang; Duncan, Emma L; Ntzani, Evangelia E; Oei, Ling; Albagha, Omar M E; Amin, Najaf; Kemp, John P; Koller, Daniel L; Li, Guo; Liu, Ching-Ti; Minster, Ryan L; Moayyeri, Alireza; Vandenput, Liesbeth; Willner, Dana; Xiao, Su-Mei; Yerges-Armstrong, Laura M; Zheng, Hou-Feng; Alonso, Nerea; Eriksson, Joel; Kammerer, Candace M; Kaptoge, Stephen K; Leo, Paul J; Thorleifsson, Gudmar; Wilson, Scott G; Wilson, James F; Aalto, Ville; Alen, Markku; ... view all 181 authors
(2012)
  • Publisher: NATURE PUBLISHING GROUP
  • Journal: Nature genetics,volume 44,issue 5,pages491-501 (issn: 1061-4036, eissn: 1546-1718)
  • Related identifiers: pmc: PMC3338864, doi: 10.1038/ng.2249
  • Subject: Fèmur | Lumbar vertebrae | Bone densitometry | Genes | Femur | Article | Genetics | Gens | /dk/atira/pure/subjectarea/asjc/1300/1311 | Vèrtebres lumbars | Densitometria òssia | Fractures
    mesheuropmc: musculoskeletal diseases

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. W... View more
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