Circulating markers of ageing and allostatic load: A slow train coming☆
Shiels, Paul G.
Kooman, Jeroen P.
- Publisher: Elsevier
Practical Laboratory Medicine,
(issn: 2352-5517, eissn: 2352-5517)
Ageing | Chronic kidney disease | Allostatic load | Exosomes | Article
Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully elucidated. Sensitive and specific biomarkers with which to interrogate the biology of the ageing process are sparse. Recent evidence suggests that non-coding RNAs are key determinants of such processes and that these can be used as potential circulatory bio-markers of ageing. They may also provide a mechanism which mediates the spread of allostatic load across the body over time, ultimately reflecting the immunological health and physiological status of tissues and organs. The interplay between exosomal microRNAs and ageing processes is still relatively unexplored, although circulating microRNAs have been linked to the regulation of a range of physiological and pathological processes and offer insight into mechanistic determinants of healthspan.