Incidence of advanced cutaneous malignant melanoma in the UK: a systematic review

Article English OPEN
Poku, E. ; Cooper, K. ; Bapat, U. ; Wang, Q.

Objectives: Cutaneous melanoma (CM) is one of the most aggressive forms of skin cancer. In 2008, CM was found to be the sixth most common cancer in the UK. The aim of this review was to systematically identify patients with advanced CM, limited to stage IIIc and stage IV disease.\ud \ud Methods: Literature searches were undertaken in the Cochrane Library, MEDLINE, CINAHL and EMBASE between December 2010 and March 2011. Webpages of the Office of National Statistics, Cancer Research UK and the Welsh Cancer Intelligence and Surveillance Unit were also scanned. A narrative synthesis was undertaken due to the heterogeneity of included studies.\ud \ud Results: Three observational studies were identified. One study was in East Anglia, England while the remaining two were in Scotland. Both studies in Scotland estimated that 2% of all melanoma patients had advanced CM at the time of diagnosis. It was also noted that, in East Anglia, the incidence of stage IV CM decreased from 0.42 to 0.13 per 100,000 population per year between 1991 and 2004. The review highlighted the challenges in identifying patients with advanced CM from available data.\ud \ud Conclusions: This review highlighted the lack of, and the need for primary studies to estimate the incidence of advanced CM in the UK. Defining this subgroup of patients is important for identifying patients for targeted treatment. We suggest that researchers must clearly define this population of patients in future studies.
  • References (32)
    32 references, page 1 of 4

    1. Cancer Research UK. Skin cancer - UK incidence statistics. Cancer Research UK. 2010. Available at: http://info.cancerresearchuk.org/cancerstats/types/skin/incidence/ (last accessed 20 November 2011).

    2. Gavin A, Walsh P. Melanoma of the skin. In: Cancer Atlas of United Kingdom and Ireland 1991-2000. The Office of National Statistics (editor). Hampshire: Macmillian Publishers Limited; 2005. pp. 151-162.

    3. Diffey BL, Diffey BL. The future incidence of cutaneous melanoma within the UK. British Journal of Dermatology 2004; 151(4): 868-872.

    4. Wang SQ, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW et al. Ultraviolet A and melanoma: a review. J Am Acad Dermatol 2001; 44(5): 837-846.

    5. Larsson P, Andersson E, Johansson U, Ollinger K, Rosdahl I. Ultraviolet A and B affect human melanocytes and keratinocytes differently. A study of oxidative alterations and apoptosis. Exp Dermatol 2005; 14(2): 117-123.

    6. Situm M, Buljan M, Bulic SO, Simic D. The mechanisms of UV radiation in the development of malignant melanoma. Coll Antropol 2007; 31 Suppl 1: 13-16 [abstract].

    7. Gray-Schopfer V, Wellbrock C, Marais R. Melanoma biology and new targeted therapy. Nature 2007; 445(7130): 851-857.

    8. Balch CM, Gershenwald JE, Soong Sj, Thompson JF, Atkins MB, Byrd DR et al. Final Version of 2009 AJCC Melanoma Staging and Classification. Journal of Clinical Oncology 2009; 27(36): 6199-6206.

    9. Leiter U, Meier F, Schittek B, Garbe C. The natural course of cutaneous melanoma. J Surg Oncol 2004; 86(4): 172-178.

    11. Marsden JR, Newton-Bishop JA, Burrows L, Cook M, Corrie PG, Cox NH et al. Revised U.K. guidelines for the management of cutaneous melanoma 2010. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS 2010; 63(9): 1401-1419.

  • Related Research Results (1)
  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    112
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    White Rose Research Online - IRUS-UK 0 112
Share - Bookmark