Seven fatalities associated with ethylphenidate

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Maskell, Peter D. ; Smith, Paul ; Cole, Richard ; Hikin, Laura ; Morley, Stephen (2016)

Ethylphenidate is a stimulant novel psychoactive substance that is an analogue of the prescription drug methylphenidate (Ritalin®). Methylphenidate is used commonly for the treatment of attention deficit hyperactivity disorder. Due to its stimulant effects ethylphenidate is being abused. There is a single case report of a death associated with ethylphenidate in Germany, and a case series of 19 deaths in the East of Scotland, but otherwise, the contribution of ethylphenidate to death is poorly documented. We report the analytical results of 7 cases (between February 2013 and January 2015) in which ethylphenidate was detected and quantitated with a validated liquid chromatography tandem mass spectrometry method (LC-MS/MS). The individuals (all male) ranged in age from 23 to 49 years (median 25 years). The concentration of ethylphenidate in the cases ranged from 0.026mg/L to 2.18mg/L in unpreserved post-mortem femoral blood. Only one case had ethylphenidate present as a sole drug. All other cases had at least 2 other drug classes present (benzodiazepines, heroin, methadone antipsychotics, other new psychoactive compounds). Ethylphenidate toxicity was the sole contribution to the cause of death in one case. Hanging was the cause of death in 2 cases, with the other 4 cases being reported as having occurred due to mixed drug toxicity. These data will further help with the interpretation of post-mortem ethylphenidate levels.
  • References (21)
    21 references, page 1 of 3

    [1] Portoghese PS, Malspeis L. Relative hydrolytic rates of certain alkyl (b) dl-alpha-(2-piperidyl)- phenylacetates. J Pharm Sci. 1961;50:494-501.

    [2] Zeitlin AL, Dariani MM. Phenidate drug formulations having diminished abuse potential. Google Patents; 2002.

    [3] Spensley J, Rockwell DA. Psychosis during methylphenidate abuse. New England Journal of Medicine. 1972;286:880-1.

    [4] EMCDDA. Annual Report: The State of the Drugs Problem in Europe. EMCDDA Lisbon; 2011.

    [5] Office H. https://www.gov.uk/government/news/legal-highs-to-be-banned-under-temporarypower. 2015.

    [6] Parks C, McKeown D, Torrance HJ. A review of ethylphenidate in deaths in east and west scotland. Forensic Science International. 2015.

    [7] Bailey GP, Ho JH, Hudson S, Dines A, Archer Jr, Dargan PI, et al. Nopaine no gain: Recreational ethylphenidate toxicity. Clinical Toxicology. 2015:1-2.

    [8] Ho JH, Bailey GP, Archer JR, Dargan PI, Wood DM. Ethylphenidate: availability, patterns of use, and acute effects of this novel psychoactive substance. European journal of clinical pharmacology. 2015;71:1185-96.

    [9] Soussan C, Kjellgren A. “Chasing the High”-Experiences of Ethylphenidate as Described on International Internet Forums. Substance abuse: research and treatment. 2015;9:9.

    [10] Stark M, Payne-James J, Scott-Ham M. Symptoms and signs of substance misuse: CRC Press; 2014.

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