Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults.

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Fujiyama, H ; Hinder, MR ; Barzideh, A ; Van de Vijver, C ; Badache, AC ; Manrique-C, MN ; Reissig, P ; Zhang, X ; Levin, O ; Summers, JJ ; Swinnen, SP

Functional motor declines that often occur with advancing age-including reduced efficacy to learn new skills-can have a substantial impact on the quality of life. Recent studies using noninvasive brain stimulation indicate that priming the corticospinal system by lowering the threshold for the induction of long-term potentiation-like plasticity before skill training may facilitate subsequent skill learning. Here, we used "priming" protocol, in which we used transcranial direct current stimulation (tDCS) applying the cathode over the primary motor cortex (M1) before the anode placed over M1 during unimanual isometric force control training (FORCEtraining). Older individuals who received tDCS with the cathode placed over M1 before tDCS with the anode placed over M1 concurrent with FORCEtraining showed greater skill improvement and corticospinal excitability increases following the tDCS/FORCEtraining protocol compared with both young and older individuals who did not receive the preceding tDCS with the cathode placed over M1. The results suggested that priming tDCS protocols may be used in clinical settings to improve motor function and thus maintain the functional independence of older adults.
  • References (59)
    59 references, page 1 of 6

    Witney 2013, Tremblay et al. 2013a, Williams et al. 2013) and older adults (Puri et al. 2016, Puri et al. 2015).

    = 1.00, p = 0.51, φ < 0.13, or sex, χ2(1, N = 60) = 0.208, p = 0.65, φ = 0.06. Importantly, however, a Fritsch, B., Reis, J., Martinowich, K., Schambra, H.M., Ji, Y.Y., Cohen, L.G., Lu, B. 2010. Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron 66(2), 198-204. doi:10.1016/j.neuron.2010.03.035.

    Fujiyama, H., Hinder, M., Garry, M., Summers, J. 2013. Slow and steady is not as easy as it sounds: interlimb coordination at slow speed is associated with elevated attentional demand especially in older adults. Exp Brain Res 227(2), 289-300. doi:10.1007/s00221-013-3511-7.

    Fujiyama, H., Hyde, J., Hinder, M.R., Kim, S.J., McCormack, G.H., Vickers, J.C., Summers, J.J. 2014. Delayed plastic responses to anodal tDCS in older adults. Front Aging Neurosci 6, 115. doi:10.3389/fnagi.2014.00115.

    Gandiga, P.C., Hummel, F.C., Cohen, L.G. 2006. Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 117(4), 845-50. doi:10.1016/j.clinph.2005.12.003.

    Goldsworthy, M.R., Hordacre, B., Ridding, M.C. 2016. Minimum number of trials required for within- and between-session reliability of TMS measures of corticospinal excitability. Neuroscience 320, 205-9. doi:10.1016/j.neuroscience.2016.02.012.

    Goodwill, A.M., Daly, R.M., Kidgell, D.J. 2015. The effects of anodal-tDCS on cross-limb transfer in older adults. Clin Neurophysiol 126(11), 2189-97. doi:10.1016/j.clinph.2015.01.006.

    Goodwill, A.M., Reynolds, J., Daly, R.M., Kidgell, D.J. 2013. Formation of cortical plasticity in older adults following tDCS and motor training. Front Aging Neurosci 5. doi:10.3389/fnagi.2013.00087.

    Heise, K.-F., Niehoff, M., Feldheim, J., Liuzzi, G., Gerloff, C., Hummel, F.C. 2014. Differential effects of anodal transcranial direct current stimulation in healthy adults of younger and older age: inhibitory neurotransmission and behavior. Front Aging Neurosci 6. doi:10.3389/fnagi.2014.00146.

    Heuninckx, S., Debaere, F., Wenderoth, N., Verschueren, S., Swinnen, S.P. 2004. Ipsilateral coordination deficits and central processing requirements associated with coordination as a function of aging. Journals of Gerontology Series B, Psychological Sciences and Social Sciences 59, 225-32. doi:doi:10.1093/geronb/59.5.P225.

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