Fc-fusion mimetics

Article English OPEN
Khalili, Hanieh ; Khaw, P. T. ; Brocchini, S. (2016)
  • Publisher: Royal Society of Chemistry
  • Related identifiers: doi: 10.1039/C6BM00077K
  • Subject:
    mesheuropmc: stomatognathic system

The Fc-fusion mimetic RpR 2[combining low line] was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR 2[combining low line] displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.
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