publication . Article . 2016

The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

Abdelkader, D H; Osman, M A; Elgizaway, S A; Faheem, Ahmed; McCarron, P A;
Open Access
  • Published: 13 Jan 2016 Journal: Journal of Analytical & Pharmaceutical Research, volume 2 (eissn: 2473-0831, Copyright policy)
  • Publisher: MedCrave Group, LLC
  • Country: United Kingdom
Abstract
Skin is a complex tissue, which comprises multiple layers. An injury to this stratified structure is considered to be the beginning of a sequence of events designed to restore skin integrity. Depending on the diameter and severity of a wound, deleterious physiological and metabolic changes can occur, leading to impaired wound healing and increased morbidity and mortality. While wound dressings provide some form of protection and remedy, the main challenge is to restore local metabolic pathways to normality, especially in the comprised patient suffering from chronic illness, such as diabetes. The implications of this disease in particular have prompted investigat...
Subjects
Medical Subject Headings: integumentary system
free text keywords: Disease, Impaired wound healing, Process mechanism, Regeneration (biology), Bioinformatics, Medicine, business.industry, business, Surgery, medicine.medical_specialty, Skin integrity, Wound healing, Diabetes mellitus, medicine.disease, Insulin, medicine.medical_treatment, sub_pharmacyandpharmacology
Related Organizations
38 references, page 1 of 3

1. Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, et al. (1999) Causal Pathways for Incident Lower-Extremity Ulcers in Patients with Diabetes from Two Settings. Diabetes Care 22(1): 157-162.

2. Falanga V (2005) Wound healing and its impairment in the diabetic foot. Lancet 366(9498): 1736 -1743.

3. Fu X, Li X, Cheng B, Chen W, Sheng Z (2005) Engineered growth factors and cutaneous wound healing: Success and possible questions in the past 10 years. Wound Repair Regen 13(2): 122-130.

4. Martin P (1997) Wound healing-aiming for perfect skin regeneration. Science 276(5309): 75-81.

5. Galkowska H, Wojewodzka U, Olszewski WL (2006) Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound [OpenAIRE]

6. Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, et al. (2007) Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 170(4): 1178-1191.

25.Goren E Müller, Schiefelbein D, Gutwein P, Seitz O, et al. (2009) Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol 129(3): 752-764.

7. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, et al. (2004) Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 164(6): 1935- 1947. [OpenAIRE]

8. Lima MH, Caricilli AM, de Abreu LL, Araújo EP, Pelegrinelli FF, et al. (2012) Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: A double-blind placebocontrolled clinical trial. PLoS One 7(5): e36974.

9. Hrynyk M, Neufeld RJ (2014) Insulin and wound healing. Burns 40(8): 1433-1446. [OpenAIRE]

26.Nakai K, Yoneda K, Moriue T, Igarashi J, Kosaka H, et al. (2009) HBEGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells. J Dermatol Sci 55(3): 170- 178.

27.Somanath JC, Byzova TV (2008) Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing. Angiogenesis. 11(3): 277-288.

28.Skolnik E Y, Lee CH, Batzer A, Vicentini, Zhou M, et al. (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosinephosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 12(5): 1929-1936.

10.Thalhimer W (1923) Insulin treatment of postoperative (nondiabetic) acidosis. J Am Med Assoc 81(5): 383-385. [OpenAIRE]

29.Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414(6865): 799-806. [OpenAIRE]

38 references, page 1 of 3
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2016

The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

Abdelkader, D H; Osman, M A; Elgizaway, S A; Faheem, Ahmed; McCarron, P A;