Hydrogen sulfide signaling: Interactions with nitric oxide and reactive oxygen species
Hancock, J. T.
- Publisher: Wiley
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Signaling in cells which involves reactive compounds is well established. Reactive oxygen species and nitric oxide are known to be extremely influential in the control of a range of physiological responses in many organisms, from animals to plants. Often their generation is triggered in reaction to stress and it is common for ROS and NO metabolism to interact to give a co-ordinated response. Recently, hydrogen sulfide (H2S) has also been found to be an important signaling molecule, being shown to be involved in vascular tone in animals. Of relevance to respiration, in plants H2S has been shown to affect stomatal apertures and the transpiration stream while in animals H2S has been shown to be a source of electrons for ATP synthesis in mitochondria. However, in signaling H2S is not working in isolation and it is likely that it will have interactions with both ROS and NO. This may be at a variety of levels, from influencing the generation of such molecules, interacting directly, or competing for control of downstream signaling events. A full understanding of the impact of this toxic molecule in the control of cells requires all these factors to be taken into account.
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