An Integrated Analog Readout for Multi-Frequency Bioimpedance Measurements

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Kassanos, P. ; Constantinou, L. ; Triantis, I. F. ; Demosthenous, A. (2014)
  • Publisher: Institute of Electrical and Electronics Engineers
  • Related identifiers: doi: 10.1109/JSEN.2014.2315963
  • Subject: TK
    acm: Hardware_INTEGRATEDCIRCUITS

Bioimpedance spectroscopy is used in a wide range of biomedical applications. This paper presents an integrated analog readout, which employs synchronous detection to perform galvanostatic multi-channel, multi-frequency bioimpedance measurements. The circuit was fabricated in a 0.35-μm CMOS technology and occupies an area of 1.52 mm2. The effect of random dc offsets is investigated, along with the use of chopping to minimize them. Impedance measurements of a known RC load and skin (using commercially available electrodes) demonstrate the operation of the system over a frequency range up to 1 MHz. The circuit operates from a ±2.5 V power supply and has a power consumption of 3.4-mW per channel.
  • References (28)
    28 references, page 1 of 3

    [1] P.Aberg,I.Nicander, J. Hansson, P. Geladi, U. Holmgren, and S. Ollmar, "Skin cancer identification using multifrequency electrical impedance-A potential screening tool," IEEE Trans. Biomed. Eng., vol. 51, no. 12, pp. 2097-2102, Dec. 2004.

    [2] L.Fabrizi, A.McEwan, T. Oh,E.J. Woo, and D.S.Holder, "A comparison of two EIT systems suitable for imaging impedance changes in epilepsy," Physiol. Meas., vol. 30, no. 6, pp. S103-S120, Jun. 2009.

    [3] U. G. Kyle et al. , "Bioelectrical impedance analysis-Part II: Utilization in clinical practice," Clin. Nutrition, vol. 23, no. 6, pp. 1430-1453, Dec. 2004.

    [4] A. D'Amico et al., "Low-voltage low-power integrated analog lock-in amplifier for gas sensor applications," Sens. Actuators B, Chem., vol. 144, no. 2, pp. 400-406, Feb. 2010.

    [5] E. Katz and I. Willner, "Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy: Routes to impedimetric immunosensors, DNA-sensors, and enzyme biosensors," Electroanalysis, vol. 15, no. 11, pp. 913-947, Jul. 2003.

    [6] D. Holmes and H. Morgan, "Single cell impedance cytometry for iden-tification and counting of CD4 T-cells in human blood using impedance labels," Anal. Chem., vol. 84, no. 4, pp. 1455-1461, Feb. 2010.

    [7] W. R. B. Lionheart, J. Kaipio, and C. N. McLeod, "Generalized optimal current patterns and electrical safety in EIT," Physiol. Meas., vol. 22, no. 1, pp. 85-90, Feb. 2001.

    [8] B. Sanchez, G. Vanderteen, R. Bragos, and J. Schoukens, "Basics of broadband impedance spectroscopy measurements using periodic exci-tations," Meas. Sci. Technol., vol. 23, no. 10, pp. 105501-1-105501-14, Oct. 2012.

    [9] A. Yufera and A. Rueda, "Design of a CMOS closed-loop system with applications to bio-impedance measurements," Microelectron. J., vol. 41, no. 4, pp. 231-239, Apr. 2010.

    [10] P. Kassanos, I. F. Triantis, and A. Demosthenous, "A CMOS magnitude/ phase measurement chip for impedance spectroscopy," IEEE Sensors J., vol. 13, no. 6, pp. 2229-2236, Jun. 2013.

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