The Current State of Peritoneal Dialysis

Article, Other literature type English OPEN
Mehrotra, R ; Devuyst, O ; Davies, SJ ; Johnson, DW (2016)

Technical innovations in peritoneal dialysis (PD), now used widely for the long-term treatment of ESRD, have significantly reduced therapy-related complications, allowing patients to be maintained on PD for longer periods. Indeed, the survival rate for patients treated with PD is now equivalent to that with in-center hemodialysis. In parallel, changes in public policy have spurred an unprecedented expansion in the use of PD in many parts of the world. Meanwhile, our improved understanding of the molecular mechanisms involved in solute and water transport across the peritoneum and of the pathobiology of structural and functional changes in the peritoneum with long-term PD has provided new targets for improving efficiency and for intervention. As with hemodialysis, almost half of all deaths on PD occur because of cardiovascular events, and there is great interest in identifying modality-specific factors contributing to these events. Notably, tremendous progress has been made in developing interventions that substantially reduce the risk of PD-related peritonitis. Yet the gains have been unequal among individual centers, primarily because of unequal clinical application of knowledge gained from research. The work to date has further highlighted the areas in need of innovation as we continue to strive to improve the health and outcomes of patients treated with PD.
  • References (113)
    113 references, page 1 of 12

    1. Ganter G: Uber die Beseitigung giftiger Stoffe aus dem Blute durch Dialyse. Munch Med Wochenschr, 70: 147-1481, 1923.

    2. Wear JB, Sisk IR, Trinkle AJ: Peritoneal lavage in the treatment of uremia: an experimental and clinical study. J Urol, 39: 53-62, 1938.

    3. Frank HA, Seligman AM, Fine J: Treatment of uremia after acute renal failure by peritoneal irrigation. JAMA : the journal of the American Medical Association, 130: 703- 705, 1946.

    4. Seligman AM, Frank HA, Fine J: Treatment of Experimental Uremia by Means of Peritoneal Irrigation. The Journal of clinical investigation, 25: 211-219, 1946.

    5. Frank HA, Seligman AM, Fine J: Further experiences with peritoneal irrigation for acuter renal failure including a description of modifications in method. Annals of surgery, 128: 561-608, 1948.

    6. Odel HM, Ferris DO, Power MH: Peritoneal lavage as an effective means of extrarenal excretion; a clinical appraisal. The American journal of medicine, 9: 63-77, 1950.

    7. Grollman A, Turner LB, Mc LJ: Intermittent peritoneal lavage in nephrectomized dogs and its application to the human being. AMA archives of internal medicine, 87: 379-390, 1951.

    8. Doolan PD, Murphy WP, Jr., Wiggins RA, Carter NW, Cooper WC, Watten RH, Alpen EL: An evaluation of intermittent peritoneal lavage. The American journal of medicine, 26: 831-844, 1959.

    9. Maxwell MH, Rockney RE, Kleeman CR, Twiss MR: Peritoneal dialysis. 1. Technique and applications. Journal of the American Medical Association, 170: 917-924, 1959.

    10. Boen ST, Mulinari AS, Dillard DH, Scribner BH: Periodic peritoneal dialysis in the management of chronic uremia. Transactions - American Society for Artificial Internal Organs, 8: 256-262, 1962.

  • Related Research Results (1)
  • Metrics
    No metrics available
Share - Bookmark