A Model of the Dynamic Relationship Between Blood Flow and Volume Changes During Brain Activation

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Kong, Y. ; Zheng, Y. ; Johnston, D. ; Martindale, J. ; Jones, M. ; Billings, S.A. ; Mayhew, J.E.W. (2004)
  • Publisher: Department of Automatic Control and Systems Engineering

The temporal relationship between changes in cerebral blood flow 9CBF) and cerebral blood volume (CBV) is still poorly understood. Grubb et al. (Grubb et al. 1974) measured steady state relationship between changes in CBV and CBF following hypercapnic challenge which has been used extensively in the modelling of haemodynamic response to activation particularly in the context of magnetic resonance imaging and the blood oxygen level dependent (BOLD) signal. More recently the 'Balloon model' (Buxton et al. 1998) and 'Windkessel model' (Mandeville et al. 1999) have been proposed to describe the temporal dynamics of changes in CBV and CBF. In the study reported here, a model based on the windkessel model incorporating delayed compliance is presented and compared with the original Windkessel model. The modified model is better able to capture the dynamics of CBF and CBV changes, particularly in the later stages.
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