Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase

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Usha, Veeraraghavan ; Lloyd, Adrian J. ; Roper, David I. ; Dowson, Christopher G. ; Kozlov, Guennadi ; Gehring, Kalle ; Chauhan, Smita ; Imam, Hasan T. ; Blindauer, Claudia A. ; Besra, Gurdyal S. (2016)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep23191, pmc: PMC4791643
  • Subject: QR | RC | RM | Article | RA

With the increased incidence of tuberculosis (TB) caused by Mycobacterium tuberculosis there is an urgent need for new and better anti-tubercular drugs. N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is a key enzyme in the succinylase pathway for the biosynthes... View more
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