Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase
Lloyd, Adrian J.
Roper, David I.
Dowson, Christopher G.
Imam, Hasan T.
Blindauer, Claudia A.
Besra, Gurdyal S.
- Publisher: Nature Publishing Group
(issn: 2045-2322, eissn: 2045-2322)
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With the increased incidence of tuberculosis (TB) caused by Mycobacterium tuberculosis there is an urgent need for new and better anti-tubercular drugs. N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is a key enzyme in the succinylase pathway for the biosynthes...