An ambient detection system for visualization of charged particles generated with ionization methods at atmospheric pressure

Article English OPEN
Hommersom, B ; Syed, SUAH ; Eijkel, GB ; Kilgour, DPA ; Goodlett, DR ; Heeren, RMA (2016)
  • Publisher: Wiley
  • Related identifiers: doi: 10.1002/rcm.7442
  • Subject:
    arxiv: Physics::Instrumentation and Detectors | Physics::Fluid Dynamics

Rationale:\ud \ud With the current state of the art detection of ions only taking place under vacuum conditions active pixel detectors that operate under ambient conditions are of particular interest. These detectors are ideally suited to study and characterize the charge distributions generated by ambient ionization sources.\ud \ud Methods:\ud \ud The direct imaging capabilities of the active pixel detector are used to investigate the spatial distributions of charged droplets generated by three ionization sources, named electrospray ionization (ESI), paper spray ionization (PSI) and surface acoustic wave nebulization (SAWN). The ionization spray (ESI/PSI) and ionization plume (SAWN) originating from each source is directly imaged. The effect of source parameters such as spray voltage for ESI and PSI, and the angle of the paper spray tip on the charge distributions is investigated. Two types of SAWN liquid interface, progressive wave (PW) and standing wave (SW) are studied.\ud \ud Results:\ud \ud Direct charge detection under ambient conditions is demonstrated using an active pixel detector. Direct charge distributions are obtained of weak, homogeneous/focussed and dispersed spray plumes by applying low, intermediate and high spray potentials, respectively, for ESI. Spray plume footprints obtained for various angles of PSI shows the possibility to focus the ion beam as a function of the paper angle. Differences between two designs of the SAWN interface are determined. Droplet charge flux changes are illustrated in a way similar to a total ion chromatogram.\ud \ud Conclusions:\ud \ud The use of this active pixel detector allows the rapid characterization and optimization of different ambient ionization sources without the actual use of a mass spectrometer. Valuable illustrations are obtained of changes in spatial distribution and number of charges detected for ESI, PSI and SAWN ion plumes.
  • References (36)
    36 references, page 1 of 4

    Annu. Rev. Biochem. 1969, 38, 289.

    R. G. Cooks, Z. Ouyang, Z. Takats, J. M. Wiseman. Ambient Mass Spectrometry. Science 2006, 311, 1566.

    F. P. M. Jjunju, A. Li, A. Badu-Tawiah. In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization. Analyst 2013, 138, 3740.

    Phys. Chem. 1984, 88, 4451.

    Z. Takáts, J. M. Wiseman, B. Gologan, R. G. Cooks. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 2004, 306, 471.

    M. Kurosawa, T. Watanabe, A. Futami, T. Higuchi. Surface acoustic wave atomizer. Sensors Actuators A Phys. 1995, 50, 69.

    S. R. Heron, R. Wilson, S. A. Shaffer, D. R. Goodlett, J. M. Cooper. Surface acoustic wave nebulization of peptides as a microfluidic interface for mass spectrometry. Anal. Chem. 2010, 82, 3985.

    Surface acoustic wave nebulization produces ions with lower internal energy than electrospray ionization. J. Am. Soc. Mass Spectrom. 2012, 23, 1062.

    S. H. Yoon, Y. Huang, J. S. Edgar, Y. S. Ting, S. R. Heron, Y. Kao, Y. Li, C. D. Masselon, R. K. Ernst, D. R. Goodlett. Surface acoustic wave nebulization facilitating lipid mass spectrometric analysis. Anal. Chem. 2012, 84, 6530.

    D. R. Goodlett, S. R. Heron, J. Cooper. Methods and Systems for Mass Spectrometry. US 2012/0145890 A1, 2012.

  • Metrics
    views in OpenAIRE
    views in local repository
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    Institutional Repository - IRUS-UK 0 63
Share - Bookmark