The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage

Article English OPEN
Meng, Qingen ; An, Shuqiang ; Damion, Robin A. ; Jin, Zhongmin ; Wilcox, Ruth ; Fisher, John ; Jones, Alison (2017)
  • Publisher: Elsevier
  • Journal: volume 65, pages 439-453 (issn: 1751-6161)
  • Related identifiers: doi: 10.1016/j.jmbbm.2016.09.001
  • Subject: Articular cartilage | /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 | Biomedical Engineering | Collagen fibril | Biomechanics | Mechanics of Materials | Research Support, Non-U.S. Gov't | DT-MRI | Journal Article | Biomaterials | Fibril-reinforced biphasic model
    mesheuropmc: macromolecular substances

<p>The highly inhomogeneous distribution of collagen fibrils may have important effects on the biphasic mechanics of articular cartilage. However, the effect of the inhomogeneity of collagen fibrils has mainly been investigated using simplified three-layered models, which may have underestimated the effect of collagen fibrils by neglecting their realistic orientation. The aim of this study was to investigate the effect of the realistic orientation of collagen fibrils on the biphasic mechanics of articular cartilage. Five biphasic material models, each of which included a different level of complexity of fibril reinforcement, were solved using two different finite element software packages (Abaqus and FEBio). Model 1 considered the realistic orientation of fibrils, which was derived from diffusion tensor magnetic resonance images. The simplified three-layered orientation was used for Model 2. Models 3–5 were three control models. The realistic collagen orientations obtained in this study were consistent with the literature. Results from the two finite element implementations were in agreement for each of the conditions modelled. The comparison between the control models confirmed some functions of collagen fibrils. The comparison between Models 1 and 2 showed that the widely-used three-layered inhomogeneous model can produce similar fluid load support to the model including the realistic fibril orientation; however, an accurate prediction of the other mechanical parameters requires the inclusion of the realistic orientation of collagen fibrils.</p>
  • References (60)
    60 references, page 1 of 6

    Ateshian, G.A., Rajan, V., Chahine, N.O., Canal, C.E., Hung, C.T., 2009. Modeling the matrix of articular cartilage using a continuous fibre angular distribution predicts many observed phenomena. J. Biomech. Eng. - Trans. ASME 131, 061003.

    Ateshian, G.A., Weiss, J.A., 2010. Anisotropic hydraulic permeability under finite deformation. J. Biomech. Eng. - Trans. ASME 132, 111004.

    Athanasiou, K.A., Rosenwasser, M.P., Buckwalter, J.A., Malinin, T.I., Mow, V.C., 1991. Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage. J. Orthop. Res. 9, 330-340.

    Atkinson, T.S., Haut, R.C., Altiero, N.J., 1998. Impact-induced fissuring of articular cartilage: An investigation of failure criteria. J. Biomech. Eng. - Trans. ASME 120, 181-187.

    Basser, P.J., Mattiello, J., Lebihan, D., 1994. Estimation of the effective self-diffusion tensor from the NMR spin echo. J. Magn. Reson. Ser. B 103, 247-254.

    Bevill, S.L., Thambyah, A., Broom, N.D., 2010. New insights into the role of the superficial tangential zone in influencing the microstructural response of articular cartilage to compression. Osteoarthr. Cartil. 18, 1310-1318.

    Clark, J.M., 1990. The organisation of collagen fibrils in the superficial zones of articular cartilage. J. Anat. 171, 117-130.

    Clark, J.M., 1991. Variation of collagen fibre alignment in a joint surface: a scanning electron microscope study of the tibial plateau in dog, rabbit, and man. J. Orthop. Res. 9, 246-257.

    Dabiri, Y., Li, L.P., 2013. Influences of the depth-dependent material inhomogeneity of articular cartilage on the fluid pressurization in the human knee. Med. Eng. Phys. 35, 1591-1598.

    de Visser, S.K., Bowden, J.C., Wentrup-Byrne, E., Rintoul, L., Bostrom, T., Pope, J.M., Momot, G., 2008. Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusiontensor measurements. Osteoarthr. Cartil. 16, 689-697.

  • Related Research Results (1)
  • Metrics
    No metrics available
Share - Bookmark