ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF THE AQUEOUS EXTRACT OF GERANIUM CAROLINIANUM L

Article English OPEN
Li, Y ; Yeung, YW ; Wang, S-J ; Xia, W ; Rahman, K ; Yue, W ; Zhang, H

Background: Geranium carolinianum L. (Geraniaceae) is widely used for a variety of diseases including herpetic keratitis, eczema, rheumatalgia etc. However, there is lack of relevant scientific research. \ud Materials and Methods: GCE (125, 250, 500mg/kg body weight) was evaluated for its pharmacological properties by using the acetic acid-induced writhing test, the hot plate test and the fresh egg white-induced paw edema in rats. The dimethylbenzene-induced mouse inflammation model and the lipopolysaccharide (LPS)-induced rat fever model were employed and the acute toxicity of GCE was also assessed.\ud Results: The Geranium carolinianum aqueous extract (GCE) significantly inhibited the writhing responses in mice, increased reaction time of mice in the hot plate test, and suppressed the fresh egg white-induced paw edema in rats and the dimethylbenzene-induced ear edema in mice whilst attenuating LPS-induced fever in rats in a dose dependent manner. Furthermore, no deaths were observed when mice were orally administered GCE up to 14 g/kg body weight (approximately 553times of clinical dose).\ud Conclusions: GCE possesses analgesic, anti-inflammatory and antipyretic activities and is non-toxic at the doses used. The results of this study support the clinical use and effectiveness of Geranium carolinianum as an analgesic, anti-inflammatory and antipyretic agent in folk medicine.\ud Key words: Plant drug; Pain; Inflammation; Pyrexia; Toxicity; Animal
  • References (14)
    14 references, page 1 of 2

    15.Ma, K.J., Zhu, Z.Z., Yu, C.H., Zhang, H., Liu, J., Qin, L.P. (2011). Analgesic, anti-inflammatory, and antipyretic activities of the ethanol extract from Desmodium caudatum. Pharm. Biol. 49:403-407.

    16.Plummer, J.L., Cmielewski, P.L., Gourlay, G.K., Owen, H., Cousins, M.J. (1991). Assessment of antinociceptive drug effects in the presence of impaired motor performance. J. Pharmacol. Meth. . 26:79-87.

    17.Saeed, M.K., Deng, Y., Dai, R., Li, W., Yu, Y., Iqbal, Z. (2010). Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl. J. Ethnopharmacol. . 127:414-418.

    18.Saha, S., Hossain, F., Anisuzzman, M., Islam, M.K. (2013). Pharmacological evaluation of Musa seminifera Lour. fruit. Journal of integrative medicine. 11:253-261.

    19.Santos, A., Vedana, E., De Freitas, G. (1998). Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. Inflamm. Res. 47:302-307.

    20. Srinivasan, K., Muruganandan, S., Lal, J., Chandra, S., Tandan, S., Raviprakash, V., Kumar, D. (2003). Antinociceptive and antipyretic activities of Pongamia pinnata leaves. Phytother. Res. 17:259-264.

    21.Trevisan, G., Rossato, M.F., Tonello, R., Hoffmeister, C., Klafke, J.Z., Rosa, F., Pinheiro, K.V., Pinheiro, F.V., Boligon, A.A., Athayde, M.L. (2014). Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice. Naunyn. Schmiedebergs. Arch. Pharmacol. 387:679-689.

    22. Wang, Y.L., Lu, M.M. (1995). Experimental study on inhibitory effect of Chinese herbs on herpes simplex virus. J. Tradi .Chin. Ophthalmo. 5:78-82.

    23. Wu, Q.Y., Zhou, Y., Jin, X., Guan, Y., Xu, M., Liu, L.F. (2011). Chromatographic fingerprint and the simultaneous determination of five bioactive components of Geranium carolinianum L. water extract by high performance liquid chromatography. Int. J. Mol. Sci. 12:8740-8749.

    24. Wu, Y.T., Jin, Z.X. (2008). The research progrosss of tannins and its and pharmacological activities from Geranium carolinianum L. Heilongjiang. Med. 21:67-68.

  • Metrics
    No metrics available
Share - Bookmark