Age-Specific Malaria Mortality Rates in the KEMRI/CDC Health and Demographic Surveillance System in Western Kenya, 2003–2010

Article English OPEN
Desai, Meghna ; Buff, Ann M. ; Khagayi, Sammy ; Byass, Peter ; Amek, Nyaguara ; van Eijk, Annemieke ; Slutsker, Laurence ; Vulule, John ; Odhiambo, Frank O. ; Phillips-Howard, Penelope A. ; Lindblade, Kimberly A. ; Laserson, Kayla F. ; Hamel, Mary J. (2014)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE (vol: 9)
  • Related identifiers: pmc: PMC4152016, doi: 10.1371/journal.pone.0106197
  • Subject: Global Health | Malarial Parasites | Research Article | Biology and Life Sciences | Public Health, Global Health, Social Medicine and Epidemiology | Infectious Diseases | Infectious Disease Epidemiology | wa_395 | wc_755 | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Tropical Diseases | Protozoans | Malaria | wc_750 | Parasitic Protozoans | Epidemiology | Plasmodium Falciparum | Public and Occupational Health | wa_900 | Organisms | Plant Science | Medicine and Health Sciences | Plant Pathology
    mesheuropmc: parasitic diseases

Recent global malaria burden modeling efforts have produced significantly different estimates, particularly in adult malaria mortality. To measure malaria control progress, accurate malaria burden estimates across age groups are necessary. We determined age-specific malaria mortality rates in western Kenya to compare with recent global estimates. We collected data from 148,000 persons in a health and demographic surveillance system from 2003-2010. Standardized verbal autopsies were conducted for all deaths; probable cause of death was assigned using the InterVA-4 model. Annual malaria mortality rates per 1,000 person-years were generated by age group. Trends were analyzed using Poisson regression. From 2003-2010, in children <5 years the malaria mortality rate decreased from 13.2 to 3.7 per 1,000 person-years; the declines were greatest in the first three years of life. In children 5-14 years, the malaria mortality rate remained stable at 0.5 per 1,000 person-years. In persons ≥15 years, the malaria mortality rate decreased from 1.5 to 0.4 per 1,000 person-years. The malaria mortality rates in young children and persons aged ≥15 years decreased dramatically from 2003-2010 in western Kenya, but rates in older children have not declined. Sharp declines in some age groups likely reflect the national scale up of malaria control interventions and rapid expansion of HIV prevention services. These data highlight the importance of age-specific malaria mortality ascertainment and support current strategies to include all age groups in malaria control interventions.
  • References (29)
    29 references, page 1 of 3

    1. Hay SI, Okiro EA, Gething PW, Patil AP, Tatem AJ, et al. (2010) Estimating the global clinical burden of Plasmodium falciparum malaria in 2007. PLoS Med 7: e1000290.

    2. WHO (2008) World Malaria Report 2008. Geneva, Switzerland: World Health Organization.

    3. WHO (2011) World Malaria Report 2011. Geneva, Switzerland: World Health Organization.

    4. Dhingra N, Jha P, Sharma VP, Cohen AA, Jotkar RM, et al. (2010) Adult and child malaria mortality in India: a nationally representative mortality survey. Lancet 376: 1768-1774.

    5. Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, et al. (2012) Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 379: 413-431.

    6. Odhiambo FO, Laserson KF, Sewe M, Hamel MJ, Feikin DR, et al. (2012) Profile: The KEMRI/CDC Health and Demographic Surveillance SystemWestern Kenya. Int J Epidemiol 41: 977-987.

    7. DOMC (2011) Kenya Malaria Indicator Survey 2010. Nairobi, Kenya: Division of Malaria Control, Ministry of Public Health and Sanitation, Kenya National Bureau of Statistics, and ICF Macro.

    8. NASCOP (2009) Kenya AIDS Indicator Survey 2007: Final Report. Nairobi, Kenya: National AIDS and STI Control Programme, Ministry of Public Health and Sanitation, Kenya.

    9. NASCOP (2013) Kenya AIDS Indicator Survey 2012: Preliminary Report. Nairobi, Kenya: National AIDS and STI Control Programme, Ministry of Health, Kenya.

    10. KEMRI/CDC (2010) KEMRI/CDC Health and Demographic Surveillance System Report for 2010. Kisumu, Kenya: Kenya Medical Research Institute and Centers for Disease Control and Prevention.

  • Related Research Results (2)
  • Metrics
    No metrics available
Share - Bookmark