Measuring vertebrate telomeres: applications and limitations\ud

Article English OPEN
Nakagawa, S. ; Gemmell, N.J. ; Burke, T. (2004)

Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic\ud chromosomes that function in stabilizing chromosomal end integrity.\ud In vivo\ud studies of\ud somatic tissue of mammals and birds have shown a correlation between telomere length and\ud organismal age within species, and correlations between telomere shortening rate and\ud lifespan among species. This result presents the tantalizing possibility that telomere length\ud could be used to provide much needed information on age, ageing and survival in natural\ud populations where longitudinal studies are lacking. Here we review methods available for\ud measuring telomere length and discuss the potential uses and limitations of telomeres as\ud age and ageing estimators in the fields of vertebrate ecology, evolution and conservation.
  • References (86)
    86 references, page 1 of 9

    Albon SD, Coulson TN, Brown D et al. (2000) Temporal changes in key factors and key age groups influencing the population dynamics of female red deer. Journal of Animal Ecology, 69, 1099 - 1110.

    Allsopp RC, Vaziri H, Patterson C et al. (1992) Telomere length predicts replicative capacity of human fibroblasts. Proceedings of the National Academy of Sciences USA, 89, 10114 - 10118.

    Aron W (2001) Scientific whaling. Science, 291, 253.

    Aviv A (2002a) Chronology versus biology: telomeres, essential hypertension, and vascular aging. Hypertension, 40, 229 - 232.

    Aviv A (2002b) Telomeres, sex, reactive oxygen species, and human cardiovascular aging. Journal of Molecular Medicine, 80, 689 - 695.

    Baird DM, Rowson J, Wynford-Thomas D, Kipling D (2003) Extensive allelic variation and ultrashort telomeres in senescent human cells. Nature Genetics, 33, 203 - 207.

    Baker C, Lento G, Cipriano F, Dalebout M, Palumbi S (2000) Scientific whaling: source of illegal products for market? Science, 290, 1695 - 1695.

    Barja G, Herrero A (2000) Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB Journal, 14, 312 - 318.

    Benetos A, Okuda K, Lajemi M et al. (2001) Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension, 37, 381- 385.

    Blackburn EH (1991) Structure and function of telomeres. Nature, 350, 569 - 573.

  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    154
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    White Rose Research Online - IRUS-UK 0 154
Share - Bookmark