The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

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Hu, Wenbing ; Luo, Qun ; Wu, Kui ; Li, Xianchan ; Wang, Fuyi ; Chen, Yi ; Ma, Xiaoyan ; Wang, Jianping ; Liu, Jianan ; Xiong, Shaoxiang ; Sadler, Peter J. (2011)

Cisplatin, cis-[Pt(Cl2(NH3)2], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.
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    Nos: 90713020, 20975103 and 21020102039), the Chinese

    Academy of Sciences (Hundred Talent Program), the 973

    30 (Grant No: 2007CB935601), European Research Council (Grant

    no. 247450) and ERDF/AWM /Science City for support, and Drs.

    Warwick and members of EC COST Action D39 for stimulating

    Chem istry, Chinese Academ y of Sciences, Beijing 100190, PR China. Fax:

    40 (+86) 10-6252-9069; E-mail:

    Coventry CV4 7AL, UK. Fax: (+44) 24-765 23818; E-mail:

    45 details of HPLC and ESI-MS/MS analysis, tryptic digestion and

    molecular modeling; Table S1 and Figure S1-S7. See

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