publication . Article . Other literature type . 2019

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial

Hausenloy, Derek J; Kharbanda, Rajesh K; Møller, Ulla Kristine; Ramlall, Manish; Aarøe, Jens; Butler, Robert; Bulluck, Heerajnarain; Clayton, Tim; Dana, Ali; Dodd, Matthew; ...
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Open Access
  • Published: 01 Oct 2019 Journal: The Lancet, volume 394, pages 1,415-1,424 (issn: 0140-6736, Copyright policy)
  • Publisher: Elsevier BV
Abstract
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were...
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doi: 10.1016/s0140-6736(19)32039-2 , 10.1038/s41569-019-0296-9
pmc: PMC6891239
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Subjects
free text keywords: General Medicine, Aged, Combined Modality Therapy, Death, Sudden, Cardiac/prevention & control, Female, Heart Failure/etiology, Hospitalization, Humans, Intention to Treat Analysis, Ischemic Preconditioning, Myocardial/methods, Male, Middle Aged, Myocardial Infarction/complications, Prospective Studies, Single-Blind Method, Treatment Outcome, United Kingdom, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016448, Multicenter Study, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016449, mortality, Cardiovascular System & Cardiology, elevation myocardial-infarction, [SDV]Life Sciences [q-bio], Article, Cardiology and Cardiovascular Medicine, RC666, Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, ST-SEGMENT ELEVATION, ISCHEMIA/REPERFUSION INJURY, TASK-FORCE, SIZE, CARDIOPROTECTION, ADJUNCT, LIMB, CONDI-2/ERIC-PPCI Investigators, 11 Medical and Health Sciences, Standard treatment, Emergency medicine, medicine.medical_specialty, medicine, Clinical endpoint, Myocardial infarction, medicine.disease, Randomized controlled trial, law.invention, law, Heart failure, Percutaneous coronary intervention, medicine.medical_treatment, Population, education.field_of_study, education, Myocardial infarction complications, business.industry, business, Clinical trial, Preclinical data, Cardiology, Internal medicine
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31 references, page 1 of 3

Szummer, K, Wallentin, L, Lindhagen, L. Improved outcomes in patients with ST-elevation myocardial infarction during the last 20 years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995–2014. Eur Heart J. 2017; 38: 3056-3065 [OpenAIRE] [PubMed]

Heusch, G, Bøtker, HE, Przyklenk, K, Redington, A, Yellon, D. Remote ischemic conditioning. J Am Coll Cardiol. 2015; 65: 177-195 [OpenAIRE] [PubMed]

Schmidt, MR, Smerup, M, Konstantinov, IE. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning. Am J Physiol Heart Circ Physiol. 2007; 292: H1883-H1890 [PubMed]

Kharbanda, RK, Mortensen, UM, White, PA. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002; 106: 2881-2883 [OpenAIRE] [PubMed]

Bøtker, HE, Kharbanda, R, Schmidt, MR. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet. 2010; 375: 727-734 [PubMed]

Rentoukas, I, Giannopoulos, G, Kaoukis, A. Cardioprotective role of remote ischemic periconditioning in primary percutaneous coronary intervention: enhancement by opioid action. JACC Cardiovasc Interv. 2010; 3: 49-55 [PubMed]

Crimi, G, Pica, S, Raineri, C. Remote ischemic post-conditioning of the lower limb during primary percutaneous coronary intervention safely reduces enzymatic infarct size in anterior myocardial infarction: a randomized controlled trial. JACC Cardiovasc Interv. 2013; 6: 1055-1063 [PubMed]

Prunier, F, Angoulvant, D, Saint Etienne, C. The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction. Basic Res Cardiol. 2014; 109: 400 [OpenAIRE] [PubMed]

Yellon, DM, Ackbarkhan, AK, Balgobin, V. Remote ischemic conditioning reduces myocardial infarct size in STEMI patients treated by thrombolysis. J Am Coll Cardiol. 2015; 65: 2764-2765 [OpenAIRE] [PubMed]

Eitel, I, Stiermaier, T, Rommel, KP. Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial. Eur Heart J. 2015; 36: 3049-3057 [OpenAIRE] [PubMed]

White, SK, Frohlich, GM, Sado, DM. Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Interv. 2015; 8: 178-188 [PubMed]

Verouhis, D, Sörensson, P, Gourine, A. Effect of remote ischemic conditioning on infarct size in patients with anterior ST-elevation myocardial infarction. Am Heart J. 2016; 181: 66-73 [OpenAIRE] [PubMed]

Sloth, AD, Schmidt, MR, Munk, K. Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention. Eur Heart J. 2014; 35: 168-175 [PubMed]

Stiermaier, T, Jensen, JO, Rommel, KP. Combined intrahospital remote ischemic perconditioning and postconditioning improves clinical outcome in ST-elevation myocardial infarction. Circ Res. 2019; 124: 1482-1491 [OpenAIRE] [PubMed]

Gaspar, A, Lourenço, AP, Pereira, MA. Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI). Basic Res Cardiol. 2018; 113: 14 [PubMed]

31 references, page 1 of 3
Related research
Abstract
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were...
Read more
doi: 10.1016/s0140-6736(19)32039-2 , 10.1038/s41569-019-0296-9
pmc: PMC6891239
View all 4 identifiers
Subjects
free text keywords: General Medicine, Aged, Combined Modality Therapy, Death, Sudden, Cardiac/prevention & control, Female, Heart Failure/etiology, Hospitalization, Humans, Intention to Treat Analysis, Ischemic Preconditioning, Myocardial/methods, Male, Middle Aged, Myocardial Infarction/complications, Prospective Studies, Single-Blind Method, Treatment Outcome, United Kingdom, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016448, Multicenter Study, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016449, mortality, Cardiovascular System & Cardiology, elevation myocardial-infarction, [SDV]Life Sciences [q-bio], Article, Cardiology and Cardiovascular Medicine, RC666, Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, ST-SEGMENT ELEVATION, ISCHEMIA/REPERFUSION INJURY, TASK-FORCE, SIZE, CARDIOPROTECTION, ADJUNCT, LIMB, CONDI-2/ERIC-PPCI Investigators, 11 Medical and Health Sciences, Standard treatment, Emergency medicine, medicine.medical_specialty, medicine, Clinical endpoint, Myocardial infarction, medicine.disease, Randomized controlled trial, law.invention, law, Heart failure, Percutaneous coronary intervention, medicine.medical_treatment, Population, education.field_of_study, education, Myocardial infarction complications, business.industry, business, Clinical trial, Preclinical data, Cardiology, Internal medicine
Related Organizations
View more
Download fromView all 23 versions
Spiral - Imperial College Digital Repository
Article . 2019
Provider: Spiral - Imperial College Digital Repository
Copenhagen University Research Information System
Article . 2019
Provider: Copenhagen University Research Information System
HAL - UPEC / UPEM
Article . 2019
Provider: HAL - UPEC / UPEM
REPISALUD
Article . 2019
Provider: REPISALUD
View more
31 references, page 1 of 3

Szummer, K, Wallentin, L, Lindhagen, L. Improved outcomes in patients with ST-elevation myocardial infarction during the last 20 years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995–2014. Eur Heart J. 2017; 38: 3056-3065 [OpenAIRE] [PubMed]

Heusch, G, Bøtker, HE, Przyklenk, K, Redington, A, Yellon, D. Remote ischemic conditioning. J Am Coll Cardiol. 2015; 65: 177-195 [OpenAIRE] [PubMed]

Schmidt, MR, Smerup, M, Konstantinov, IE. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning. Am J Physiol Heart Circ Physiol. 2007; 292: H1883-H1890 [PubMed]

Kharbanda, RK, Mortensen, UM, White, PA. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002; 106: 2881-2883 [OpenAIRE] [PubMed]

Bøtker, HE, Kharbanda, R, Schmidt, MR. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet. 2010; 375: 727-734 [PubMed]

Rentoukas, I, Giannopoulos, G, Kaoukis, A. Cardioprotective role of remote ischemic periconditioning in primary percutaneous coronary intervention: enhancement by opioid action. JACC Cardiovasc Interv. 2010; 3: 49-55 [PubMed]

Crimi, G, Pica, S, Raineri, C. Remote ischemic post-conditioning of the lower limb during primary percutaneous coronary intervention safely reduces enzymatic infarct size in anterior myocardial infarction: a randomized controlled trial. JACC Cardiovasc Interv. 2013; 6: 1055-1063 [PubMed]

Prunier, F, Angoulvant, D, Saint Etienne, C. The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction. Basic Res Cardiol. 2014; 109: 400 [OpenAIRE] [PubMed]

Yellon, DM, Ackbarkhan, AK, Balgobin, V. Remote ischemic conditioning reduces myocardial infarct size in STEMI patients treated by thrombolysis. J Am Coll Cardiol. 2015; 65: 2764-2765 [OpenAIRE] [PubMed]

Eitel, I, Stiermaier, T, Rommel, KP. Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial. Eur Heart J. 2015; 36: 3049-3057 [OpenAIRE] [PubMed]

White, SK, Frohlich, GM, Sado, DM. Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Interv. 2015; 8: 178-188 [PubMed]

Verouhis, D, Sörensson, P, Gourine, A. Effect of remote ischemic conditioning on infarct size in patients with anterior ST-elevation myocardial infarction. Am Heart J. 2016; 181: 66-73 [OpenAIRE] [PubMed]

Sloth, AD, Schmidt, MR, Munk, K. Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention. Eur Heart J. 2014; 35: 168-175 [PubMed]

Stiermaier, T, Jensen, JO, Rommel, KP. Combined intrahospital remote ischemic perconditioning and postconditioning improves clinical outcome in ST-elevation myocardial infarction. Circ Res. 2019; 124: 1482-1491 [OpenAIRE] [PubMed]

Gaspar, A, Lourenço, AP, Pereira, MA. Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI). Basic Res Cardiol. 2018; 113: 14 [PubMed]

31 references, page 1 of 3
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