Nutrients and environmental factors as regulators of gene expression

Article English OPEN
Gustafsson, Jan-Åke ; Enmark, Eva (2002)
  • Publisher: Co-Action Publishing
  • Journal: Food & Nutrition Research (issn: 1654-661X, eissn: 1654-6628)
  • Related identifiers: doi: 10.3402/fnr.v46i1.1428

Several nuclear receptors bind substances in the diet or metabolites of dietary substances. This makes nuclear receptors a fascinating link between nutrition, toxicology, endocrinology and molecular biology. Nuclear receptor ligands may broadly be divided into two groups. The first group consists of steroid and thyroid hormones, and compounds that constitute intermediates in different biosynthetic pathways in steroid hormone, sterol and bile acid biosynthesis. The second group consists of the very diverse array of compounds that, with no or minor modifications, directly originate from foods, drugs or environmental pollutants. This review summarizes recent results on nuclear receptors with an emphasis on those with ligands of dietary relevance. The finding that several dietary compounds regulate gene expression in the same manner as steroid hormones has provided tools to help unravel molecular secrets and mechanisms behind many diet-associated diseases such as diab etes and obesity. Keywords: Cholesterol, fatty acid, nuclear receptor, orphan receptor, phyto-oestrogen, vitamin.
  • References (50)
    50 references, page 1 of 5

    1. Enmark E, Gustafsson JA: Comparing nuclear receptors in worms, ies and humans. Trends Pharmacol Sci 2001;22:61 1-5.

    2. Giguere V: Orphan nuclear receptors: from gene to function. Endocr Rev 1999;20:68 9-725.

    3. Gronemeyer H, Laudet V: Transcription factors 3: nuclear receptors. Protein Pro le 1995;2:1173-308.

    4. McKenna NJ, Xu J, Nawaz Z et al: Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol 1999;69:3 -12.

    5. Song C, Liao S: Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha. Endocrinology 2000;141:418 0- 4.

    6. Janowski BA, Grogan MJ, Jones SA et al: Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci USA 1999;96:26 6- 71.

    7. Lehmann JM, Kliewer SA, Moore LB et al: Activation of the nuclear receptor LXR by oxysterols de nes a new hormone response pathway. J Biol Chem 1997;272:313 7 -40.

    8. Peet DJ, Turley SD, Ma W et al: Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 1998;93:693 - 704.

    9. Alberti S, Schuster G, Parini P et al: Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-de cient mice. J Clin Invest 2001;107 :565- 73.

    10. Repa JJ, Liang G, Ou J et al: Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000;14:281 9 -30.

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