Adult human RPE for transplantation: renewing an old promise

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Blenkinsop, Timothy A. (2015)
  • Publisher: Advances in Regenerative Biology
  • Journal: Advances in Regenerative Biology (issn: 2001-8517, eissn: 2001-8517)
  • Related identifiers: doi: 10.3402/arb.v2.27144
  • Subject: adult stem cell;retinal pigment epithelium; cell transplantation; eye disease
    mesheuropmc: eye diseases | sense organs

Considering the incidence of retinal pigment epithelium (RPE)-related blinding disease will grow to 200 million globally by 2020, the impact of restoring vision by successfully replacing failing or dying RPE is great. In spite of fervent efforts to use primary RPE as a source for transplantation for over 30 years, a clinical therapy has yet to be developed. Due to the progress of pluripotent stem cell technologies and development of RPE differentiation protocols, primary human RPE culture has largely been set aside as a source of RPE for transplantation, as human embryonic stem cell (hESC)- and induced pluripotent stem cell (hiPSC)-derived RPE have become the current popular source for transplantation. Recently, a series of seminal advances in human primary RPE culture has renewed an interest in their potential as a source for RPE transplantation. Primary RPE are better studied and understood than hESC/hiPSC-derived RPE, have an inherent lower risk of tumor formation, and can be Major Histocompatibility Complex (MHC) donor-matched, making them valuable candidates alongside pluripotent stem cells as sources for cell transplantation therapy for RPE-related eye diseases.Keywords: adult stem cell; retinal pigment epithelium; cell transplantation; eye disease(Published: 7 April 2015)Citation: Advances in Regenerative Biology 2015, 2: 27144 - http://dx.doi.org/10.3402/arb.v2.27144
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