Effect of Supplements with Bifidobacteriurn longum and Lactobacillus acidophilus on the Intestinal Microbiota during Administration of Clindamycin

Article English OPEN
Orrhage, K. ; Brismar, B. ; Nord, C. E. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v7i1.8155
  • Subject:
    mesheuropmc: food and beverages | digestive system | fluids and secretions

Thirty healthy volunteers in three groups participated in a study of the influence of supplements containing Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microbiota during administration of clindamycin. All groups received clindamycin perorally q.d.s. for 7d. Group I also received a supplement with B. longum and L. acidophilus, group II received a supplement with B. longum and group III received a placebo, for 21 d. The numbers of anaerobic microorganisms decreased in all groups, but the reduction of bacteroides was significantly smaller in group I than in group III (P<0.05). No subject in group III had any intestinal bifidobacteria on day 7. Significant decreases of volatile fatty acids in faecal specimens were seen (P<0.05). There was a smaller incidence of gastrointestinal discomfort in group I than in group III (P<0.05).Keywords - Bifidobacterium longum, Lactobacillus acidophilus, Probiotics, Clindamycin, Supplementation, Intestinal microbiota (microflora), Volatile fatty acids.
  • References (34)
    34 references, page 1 of 4

    1. Aronsson B, Mollby R, Nord CE.(1981). Occurrence of toxin producing Clostridium dificile in antibiotic associated diarrhea in Sweden. Medical Microbiology and Immunology 110,27-35.

    2. Aronsson B, Mollby R, Nord CE. (1985). Antimicrobial agents and Clostridium dificile in acute enteric disease: epidemiological data from Sweden 1980-1982. Journal of Infectious Diseases 151, 476-48 I .

    3 . Beerens H. (1990).An electiveand selectiveisolation medium for Bijidobacterium spp. Letters in Applied Microbiology 11, 155-157.

    4. Biasco G, Paganelli GM. Brandi G , Brillanti S, Lami F, Callegari C, Gizzi G. (1991). Effect of Lactobacillus acidophilusand Bijidobacterium bifidum on rectal cell kinetics and fecal pH. Italian Journalof Gastroenterology 23, 142.

    5. Black F, Einarsson K, Lidbeck A, Orrhage K, Nord CE. (1991). Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. Scandinavian Journal of Infectious Diseases 23,2417254.

    6. Borthen L, Heimdahl A, Lindqvist L, Nord CE. (1983). Determination of volatile fatty acids in saliva and faeces by gas-liquid chromatography: a rapid method for detection of antibiotic-induced changes in the oropharyngeal and gastrointestinal microflora. International Journal o f Microbiology 1, 3 5 4 5 .

    7. Colombel JF, Cortot A, Neut C, Romond C. (1987).Yoghurt with Bijidobacterium longum reduces erythromycin-inducedgastrointestinaleffects. Lancet ii, 43.

    8 . Erlich M, van Tassel RL, Libby JM, Wilkins TD. (1980). Production of Clostridium dijicile antitoxin. Infection and Immunity 28, 1041-1043.

    9. George WL, Rolfe RD, Finegold SM. (1982). Clostridium difJicile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions. Journal o f Clinical Microbiology 15, 1049-1053.

    10. George WL, Sutter VL, Citron D, Finegold SM. (1976). Selective and differential medium for isolation of Clostridium di9cile. Journul of Clinical Microbiology 9 , 2 14-2 19.

  • Metrics
    No metrics available
Share - Bookmark