Effect of Supplements with Bifidobacteriurn longum and Lactobacillus acidophilus on the Intestinal Microbiota during Administration of Clindamycin
Nord, C. E.
- Publisher: Microbial Ecology in Health and Disease
Microbial Ecology in Health and Disease
(issn: 1651-2235, eissn: 1651-2235)
mesheuropmc: food and beverages | digestive system | fluids and secretions
Thirty healthy volunteers in three groups participated in a study of the influence of supplements containing Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microbiota during administration of clindamycin. All groups received clindamycin perorally q.d.s. for 7d. Group I also received a supplement with B. longum and L. acidophilus, group II received a supplement with B. longum and group III received a placebo, for 21 d. The numbers of anaerobic microorganisms decreased in all groups, but the reduction of bacteroides was significantly smaller in group I than in group III (P<0.05). No subject in group III had any intestinal bifidobacteria on day 7. Significant decreases of volatile fatty acids in faecal specimens were seen (P<0.05). There was a smaller incidence of gastrointestinal discomfort in group I than in group III (P<0.05).Keywords - Bifidobacterium longum, Lactobacillus acidophilus, Probiotics, Clindamycin, Supplementation, Intestinal microbiota (microflora), Volatile fatty acids.