Short-chain fatty acid formation at fermentation of indigestible carbohydrates

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Henningsson, Åsa ; Björck, Inger ; Nyman, Margareta (2001)
  • Publisher: Co-Action Publishing
  • Journal: Food & Nutrition Research (issn: 1654-661X, eissn: 1654-6628)
  • Related identifiers: doi: 10.3402/fnr.v45i0.1801
  • Subject:
    mesheuropmc: food and beverages | digestive, oral, and skin physiology

Short chain fatty acids (SCFAs; acetic, propionic and butyric acid) are formed during bacterial fermentation of carbohydrates in the colon. The interest in SCFA production is related to an increasing body of knowledge of the physiological effects of these acids. SCFAs are important anions in the colonic lumen and serve locally as nutrients for the mucosa cells, stimulating mucosal proliferation and blood flow. Especially butyric acid has been emphasized. It is the main energy substrate for the colonocytes and has been suggested to play a role in the prevention and treatment of diseases of the colonic mucosa, such as distal ulcerative colitis and cancer. SCFA production decreases the luminal pH, and may thereby stimulate mineral absorption and reduce secondary bile acid formation in the colon. Colonic generation of SCFAs has also been related to systematic and metabolic effects, e.g. SCFAs may influence the motility along the gastrointestinal tract and propionic acid has been suggested to inhibit the cholesterol synthesis from acetic acid in the liver. The SCFA formed at fermentation is quantitatively and qualitatively influenced by the type and amount of carbohydrate substrate. Further, certain combinations of carbohydrates may have synergistic effects on the SCFA pattern and may also shift the site of fermentation. This opens possibilities to design foods with tailored features regarding SCFA release in the human colon with potential health implications. There is a potential that in the future it will be possible to control SCFA production in the colon regarding pattern and place for release. Keywords: Carbohydrates, dietary fibre, fermentation, SCFA, resistant starch
  • References (68)
    68 references, page 1 of 7

    Cummings JH, Macfarlane GT: The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 1991;70:443-59.

    Moore WE, Cato EP, Holdeman LV: Some current concepts in intestinal bacteriology. Am J Clin Nutr 1978;31:S33-42.

    Ruppin H, Bar-Meir S, Soergel KH, Wood CM, Schmitt MG, Jr.: Absorption of short-chain fatty acids by the colon. Gastroenterology 1980;78: 1500-17.

    McNeil NI: The contribution of the large intestine to energy supplies in man. Am J Clin Nutr 1984;39:338-42.

    Clausen MR, Mortensen PB: Kinetic studies on the metabolism of shortchain fatty acids and glucose by isolated rat colonocytes. Gastroenterology 1994;106:423-32.

    Remesy C, Demigne C, Morand C: Metabolism and utilization of short chain fatty acids produced by colonic fermentation. In: Schweizer TF, Edwards CA, eds. Dietary Fibre- A Component of Food, Springer, London, UK 1992; 137-50.

    Wolever TMS (1995) Short-chain fatty acids and carbohydrate metabolism.

    Scheppach W, Pomare EW, Elia M, Cummings JH: The contribution of the large intestine to blood acetate in man. Clin Sci 1991;80:177-82.

    Thorburn A, Muir J, Proietto J: Carbohydrate fermentation decreases hepatic glucose output in healthy subjects. Metabolism 1993;42:780-5.

    Anderson JW, Bridges SR: Short-chain fatty acid fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes. Proc Soc Exp Biol Med 1984;177:372-6.

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