Mechanisms involved in the intestinal interaction between host and bifidobacteria

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Candela, Marco ; Biagi, Elena ; Turroni, Sivia ; Vitali, Beatrice ; Brigidi, Patrizia (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v20i4.7575
  • Subject:
    mesheuropmc: food and beverages | digestive system | fluids and secretions

Bifidobacteria constitute up to 3% of the total human intestinal microbiota and represent one of the most important healthpromoting bacterial groups of the gut microbial ecosystem. Recently, the interaction between Bifidobacterium and the human plasminogen system has been reported, raising the question of the role of this system in the bifidobacterial ecology in the human gastrointestinal tract. Here we investigate the effect of plasminogen on the adhesion of Bifidobacterium lactis BI07 to enterocyte-like Caco-2 cells. According to our experimental data, in the presence of human plasminogen the adhesion of B. lactis BI07 to Caco-2 cells significantly increases. Therefore, we can hypothesize a plasminogen-mediated early adhesion step of B. lactis BI07 to Caco-2 cells. Our findings open the way for further investigations to thoroughly assess the role of plasminogen in the interaction between bifidobacteria and host enterocytes.Key words: Bifidobacteria, plasminogen, enterocytes, gastrointestinal tract, microbiota, adhesion
  • References (19)
    19 references, page 1 of 2

    1. Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host/bacterial mutualism in the human intestine. Science. 2005;/307:/1915 20.

    2. Zoetendal EG, Vaughan EE, De Vos WM. A microbial world within us. Mol Microbiol. 2006;/59:/1639 50.

    3. Klijn A, Mercenier A, Arigoni F. Lessons from the genomes of bifidobacteria. FEMS Microbiol Rev. 2005;/29:/491 509.

    4. Schell MA, Karmirantzou M, Snel B, Vilanova D, Berger B, Pessi G, et al. The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proc Natl Acad Sci U S A. 2002;/99:/14422 7.

    5. Servin AL. Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiol Rev. 2004;/28:/405 40.

    6. Candela M, Bergmann S, Vici M, Vitali B, Turroni S, Eikmanns BJ, et al. Binding of human plasminogen to Bifidobacterium. J Bacteriol. 2007;/189:/5929 36.

    7. Vassalli JD, Sappino AP, Belin D. The plasminogen activator/ plasmin system. J Clin Invest. 1991;/88:/1067 72.

    8. Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, et al. Plasminogen has a broad extrahepatic distribution. Thromb Haemost. 2002;/87:/493 501.

    9. Bergmann S, Hammerschmidt S. Fibrinolysis and host response in bacterial infections. Thromb Haemost. 2007;/98:/ 512 20.

    10. Sun H. The interaction between pathogens and host coagulation system. Physiology. 2005;/21:/281 8.

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