A clinical study on the effect of the prebiotic inulin in the control of oral malodour

Article English OPEN
Doran, Anna Louise ; Verran, Joanna (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v19i3.7663

The aim of this clinical study was to evaluate the potential of an inulin mouth rinse to reduce the proportions of tongue bacteria associated with oral malodour. Thirteen panellists rinsed with either 10% sucrose or a 10% inulin mouth rinse twice daily for 21 days. Breath odour levels were assessed using a Halimeter† and organoleptic assessment, both before and after sucrose, inulin or water rinses. Tongue pH was registered and the tongue flora was cultured on media selective for total and obligate anaerobes, streptococci and inulin fermenters. There were no differences in baseline Halimeter† levels over the 21 day period, but a slight decrease in organoleptic scores was noted. A reduction in odour levels assessed by Halimeter† and organoleptically was observed immediately after rinsing. The effect was greater by the end of the 21 day regime. Microbial counts remained high, and no significant differences were observed, but there was a trend towards increased streptococcal counts by the end of the 21 day period. Tongue pH baseline levels were approximately neutral, but immediately after carbohydrate rinses a typical Stephan curve was observed. There is some indication that the use of twicedaily carbohydrate mouth rinses (sucrose or the prebiotic inulin) can reduce oral malodour by encouraging the growth of acidogenic bacteria and inhibiting the obligate anaerobes associated with malodour. Inulin is a less cariogenic substrate, and inulin mouth rinsing may provide a novel method for the control of oral malodour.Key words: oral malodour, volatile sulphur compounds, prebiotic, inulin, oral bacteria
  • References (20)
    20 references, page 1 of 2

    1. Reingewirtz Y, Girault O, Reingewirtz N, Senger B, Tenebaum H. Mechanical effects and volatile sulphur compoundreducing effects of chewing gums: comparison between test and base gums and a control group. Quintessence Int. 1999;/ 30:/319 23.

    2. Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 1994;/8:/ 263 71.

    3. Verran J, Doran AL, Smith C. Denture stomatitis, oral malodour and oral biofilm ecology. In: Gilbert P, Alison D, Brading M, Verran J, Walker J. editors. Biofilm community interactions: chance or necessity? Cardiff: BioLine; 2001. p. 131 40.

    4. McNamara TF, Alexander JF, Lee M. The role of microorganisms in the production of oral malodour. Oral Surg Oral Med Oral Pathol. 1972;/34:/41 8.

    5. Doran A, Kneist S, Verran J. Ecological control: in vitro inhibition of anaerobic bacteria by oral streptococci. Microb Ecol Health Dis. 2004;/16:/23 7.

    6. Gibson GR, Beatty ER, Wang X, Cummings JH. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology. 1995;/108:/975 82.

    7. Marsh P, Martin M. Oral microbiology, 4th edn. Oxford: Wright; 1999.

    8. Kazor CE, Mitchell PM, Lee AM, Stokes LN, Loesche WJ, Dewihurst FE, et al. Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. J Clin Microbiol. 2003;/41:/558 63.

    9. Burton JP, Chilcott CN, Moore CJ, Speiser G, Tagg JR. A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. J Appl Microbiol. 2006;/100:/754 64.

    10. Doran AL, Greenman J, Verran J. Approaches to the control of oral malodour I: a clinical study on the antimicrobial and breath-freshening effect of zinc-containing lozenge formulations. Microb Ecol Health Dis 2007 (in press).

  • Similar Research Results (1)
  • Metrics
    No metrics available
Share - Bookmark