Mechanisms of Colonisation and Colonisation Resistance of the Digestive Tract

Article English OPEN
Alderberth, Ingegerd ; Cerquetti, Marina ; Poilance, Isabelle ; Wold, Agnes ; Collignon, Anne (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v12i2.8060

The digestivemicroflora is characterized by a high degree of complexity and diversity. Variation in the composition of the digestive flora of an individual occurs in space and time. Two kinds of strains can be defined: transient strains in opposition to resident strains, which are repeatedly isolated from the digestive tract over a long period of time. The latter can be assumed to have colonized the digestive tract. We will present here studies on the properties of bacteria implicated in the colonisation process. Firstly, we summarize data on the role of adherence in this process, the mechanisms involved in adhesion to mucosal structures (cellular and mucus glycoproteins, extracellular matrix components) and give examples of adhesion in various intestinal bacterial groups (commensal and potentially pathogenic bacteria). Secondly, we describe the role of glucidolytic and proteolytic enzymes involved in host-bacteria interactions and implicated in colonisation and maintenance of the indigenous intestinal flora.Keywords: colonisation, colonisation resistance, bacterial adherence, bacterial metabolic enzymes.
  • References (229)
    229 references, page 1 of 23

    1. Adlerberth I, Jalil F, Carlsson B, et al. High turn over rate of Escherichia coli strains in the intestinal ora of infants in Pakistan. Epidemiol Infect 1998; 121: 587- 98.

    2. Tannock GW. In: Hanson LAÎ , Yolken RH, eds. Probiotics, other nutritional factors and intestinal micro ora. Vevey: Lipincott-Raven Publishers, Philadelphia: Nestle´ Nutrition Workshop Series, 1999; 42, pp. 17- 31.

    3. Sears HJ, Brownlee I, Uchiyama JK. Persistence of individual strains of Escherichia coli in the intestinal tract of man. J Bacteriol 1949; 59: 299- 301.

    4. Sears HJ, Brownlee I. Further observations on the persistence of individual strains of Escherichia coli in the intestinal tract of man. J Bacteriol 1951; 63: 47- 57.

    5. Sears HJ, James H, Saloum R, Brownlee I, Lameraux LF. Persistence of individual strains of Escherichia coli in man and dog under varying conditions. J Bacteriol 1956; 71: 370- 2.

    6. Lari AR, Gold F, Borderon JC, Laugier J, Lafont JP. Implantation and in vivo antagonistic effects of antibioticsusceptible Escherichia coli strains administered to premature newborns. Biol Neonate 1990; 58: 73- 8.

    7. Poisson DM, Borderon JC, Amorim-Sena JC, Laugier J. Evolution of the barrier effects against an exogenous drugsensitive Escherichia coli strain after single or repeated oral administration to newborns and infants aged up to three months admitted to an intensive care unit. Biol Neonate 1986; 49: 1 - 7.

    8. Havenaar R, ten Brink B, Huis in t'Veld JHJ. Selection of strains for probiotic use. In: Fuller R, ed. Probiotics, the scienti c basis. London: Chapman and Hall, 1992, pp. 209- 24.

    9. Beachley EH. Bacterial adherence: adhesine receptor interactions mediating the attachment of bacteria to mucosal surface. J Infect Dis 1981; 143: 325.

    10. Ahrne´ S, Nobaek S, Jeppsson B, Adlerberth I, Wold AE, Molin G. The normal Lactobacillus ora of healthy human oral and rectal mucosa. J Appl Microbiol 1998; 85: 88- 94.

  • Metrics
    No metrics available
Share - Bookmark