Genetics of asthma: an introduction for the clinician

Article English OPEN
Thomsen, Simon F. (2015)
  • Publisher: Co-Action Publishing
  • Journal: European Clinical Respiratory Journal (vol: 2)
  • Related identifiers: doi: 10.3402/ecrj.v2i0.24643, doi: 10.3402/ecrj.v2.24643, pmc: PMC4629762
  • Subject: Review Article | genetics | Asthma; genetics; genetic epidemiology; pharmacogenetics | gene discovery | linkage analysis | association analysis | asthma | epigenetics | pharmacogenetics | genetic epidemiology
    mesheuropmc: respiratory tract diseases

Asthma runs in families, and children of asthmatic parents are at increased risk of asthma themselves. Prediction of disease risk is pivotal for the clinician when counselling atopic families. However, this is not always an easy task bearing in mind the vast and ever increasing knowledge about asthma genetics. The advent of new genotyping technologies has made it possible to sequence in great detail the human genome for asthma associated variants, and accordingly, recent decades have witnessed an explosion in the number of rare and common variants associated with disease risk. This review presents an overview of methods and advances in asthma genetics in an attempt to help the clinician keeping track of the most important knowledge in the field.
  • References (26)
    26 references, page 1 of 3

    1. Palmer LJ, Cookson WOCM. Atopy and asthma. In: Bishop T, Sham P, eds. Analysis of multifactorial disease. Oxford: BIOS; 2000, pp. 215 37.

    2. Asher MI, Montefort S, Bjo¨ rkste´n B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006; 368: 733 43.

    3. Thomsen SF, van der Sluis S, Kyvik KO, Skytthe A, Backer V. Estimates of asthma heritability in a large twin sample. Clin Exp Allergy. 2010; 40: 1054 61.

    4. Thomsen SF, Duffy DL, Kyvik KO, Backer V. Genetic influence on the age at onset of asthma: a twin study. J Allergy Clin Immunol. 2010; 126: 626 30.

    5. Thomsen SF, van der Sluis S, Kyvik KO, Backer V. A study of asthma severity in an adult twin sample. Clin Respir J. 2012; 6: 228 37.

    6. McGuffin P, Owen MJ, Gottesman II. Psychiatric genetics and genomics. Oxford: Oxford University Press; 2002.

    7. Cookson WO, Sharp PA, Faux JA, Hopkin JM. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet. 1989; 1: 1292 5.

    8. Bosse´ Y, Hudson TJ. Toward a comprehensive set of asthma susceptibility genes. Annu Rev Med. 2007; 58: 171 84.

    9. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol. 2008; 8: 169 82.

    10. Bisgaard H, Simpson A, Palmer CN, Bønnelykke K, McLean I, Mukhopadhyay S, et al. Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Med. 2008; 5: e131.

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