The Influence of Hormones on the Bacterial Flora of the Murine Vagina and Implications for Human Disease

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Furr, P. M. ; Taylor-Robinson, D. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v4i3.7636
  • Subject:
    mesheuropmc: endocrine system

Oestradiol or progesterone administered to groups of young female B’alb C mice affected their reproductive cycle compared to that of untreated mice. The cycle of oestradiol-treated mice arrested in the oestrous phase within about 24 h and there was a concomitant increase in the bacterial flora of the vagina with many epithelial cells studded with bacteria. However, progesterone-treated mice required longer to arrest the cycle in the dioestrous phase with virtual disappearance of bacteria. The similarities between the features of the oestradiol-stimulated events in mice and those of bacterial vaginosis in women suggest that the latter condition might be stimulated hormonally.Keywords: Hormones; Vaginal flora; Mouse vagina.
  • References (17)
    17 references, page 1 of 2

    1. Amsel R, Totten PA, Spiegel CA, Chen KCS, Eschenbach D, Holmes KK. (1983). Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. American Journal of Medicine 74, 1422.

    2. Bartlett JG, Onderdonk AB, Drude E, Goldstein C, Anderka M, Alpert S, McCormack WM. (1977). Quantitative bacteriology of the vaginal flora. Journal of Infectious Diseases 136,271-277.

    3. Biggers JD. (1953). The carbohydrate components of the vagina of the normal and ovariectamized mouse during oestrogenic stimulation. Journal of Anatomy 87,327-337.

    4. Braude AI, Corbeil LB, Levine S, Ito J, McCutchan JA. (1978). Possible influence of cyclic menstrual changes on resistance to the gonococcus, In: Brooks GF (ed) lmmunobiology of Neisseria gonorrhoeae. American Society of Microbiology, Washington, pp. 328-337.

    5. Coombs GH, Bremner AF, Markham DJ, Latter VS, Walters MA, North MJ. (1986). Intravaginal growth of Trichomonas vaginalis in mice. Acta Universitatis Carolinae-Biologica 30,387-392.

    6. Eschenbach DA, Bekassy S, Blackwell A, Ekgren J, HallCn A, Wathne B. (1984). The diagnosis of bacterial vaginosis. In: Mirdh P-A, Taylor-Robinson D (eds) Bacterial Vaginosis. Almqvist and Wiksell, Stockholm, pp. 260-261.

    7. Forslin L, Danielsson D, Falk V. (1979). Variations in attachment of Neisseria gonorrhoeae to vaginal epithelial cells during the menstrual cycle and early pregnancy. Medical Microbiology and Immunology 167,23 1-238.

    8. Furr PM, Taylor-Robinson D. (1989). The establishment and persistence of Ureaplasma urealyticum in oestradiol-treated female mice. Journal of Medical Microbiology 29, 111-1 14.

    9. Furr PM, Taylor-Robinson D. (1989). Oestradiolinduced infection of the genital tract of female mice by Mycoplasma hominis. Journal of General Microbiology 135,2743-2749.

    10. Koiter TR, Hazenberg MP, Van der Schoot P. (1977). Regulation of the bacterial flora of the vagina in cyclic female rats. Journal ofExperimenta1 Zoology202,121-128.

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