Suppressive effects of lactulose and magnesium oxide supplementation on fecal putrefactive metabolites with shortening gastrointestinal transit time

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Ishikado, Atsushi ; Sato, Takehiko ; Mitsuoka, Tomotari (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v19i3.7653

Gastrointestinal transit time (GTT) denotes the time required for foodstuffs to pass through the gut. As a long GTT might accumulate colonic putrefactive metabolites, shortening the GTT has been considered important to prevent diseases of the large bowel such as colon cancer. However, apart from but dietary fibers as such as bran, few supplementations are known to shorten the GTT. In time series trials, we examined the shortening effects of a dietary supplement comprising 1.0 g of disaccharide lactulose and 0.53 g of magnesium oxide. GTTwas measured by detecting radio-opaque markers in collected stools. Supplementation for 2 weeks in 13 healthy females showed a significantly reduced mean GTT from 67.9 to 43.9 h and tended to increase daily stool weight compared with values before supplementation. At the same time, fecal pH was significantly elevated and fecal moisture significantly increased. This supplementation resulted in significant decreases in fecal concentrations of p-cresol, indole, and ammonia and a tendency to decreases in skatol, but phenol and 4E-phenol were not affected. Multiple regression analysis detected a strong inverse correlation between fecal moisture and total putrefactive metabolites (R=-0.773, p=0.019), which were the sum of phenol, p-cresol, 4E-phenol, indole, and skatol. In healthy humans, this supplement shortened the GTT and increased fecal moisture and suppressed fecal total putrefactive metabolites.Key words: gastrointestinal transit time, lactulose, magnesium oxide, fecal putrefactive metabolites
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