Randomized, placebo-controlled trial on clinical and immunologic effects of probiotic containing Lactobacillus rhamnosus R0011 and L. helveticus R0052 in infants with atopic dermatitis

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Chernyshov, Pavel V. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v21i3-4.7511

Background and aim: A benefi cial role of probiotics, especially Lactobacillus rhamnosus, in children with atopic dermatitis (AD) has been reported. Their effects are primarily mediated through immune pathways, which need further investigation. This study aimed to investigate clinical and immunologic effects of probiotics in the treatment of children with AD. Methods: Thirty children with AD received probiotic Lacidofi l and 28 other children with AD received placebo, one capsule per day. All children used emollient Trixera. SCORAD, specifi c IgE, specifi c IgG4 to cow’s milk, CD45RA+, CD45RO+ and transitional CD45RA+RO+ CD4+ T cells were studied at day 1 and day 30. Results: Marked reduction of SCORAD in 63.3% of patients in the treatment group and in 32.1% in the placebo group was reported. The decline of SCORAD in patients who did not use topical steroids during the follow-up period was signifi cant in the treatment group (p < 0.01) and not signifi cant in the placebo group. After the treatment, levels of specifi c IgG4 to cow’s milk increased (p < 0.001) and percentages of transitional recently activated CD45RA+RO+ T cells decreased (p < 0.05). Conclusion: The use of probiotic Lacidofi l was associated with a higher number of patients who achieved marked clinical improvement and higher corticosteroid-sparing effect. Synergistic action of Lacidofi l and emollient Trixera was also confi rmed by signifi cant decline of transitional recently activated CD45RA+RO+ CD4+ T cells. We found significant increase of the levels of specific IgG4 to cow’s milk in the group of patients who received probiotic and emollient that was not reported in the treatment group and may be considered as a shift to tolerance.Key words: Emollients, T lymphocyte
  • References (34)
    34 references, page 1 of 4

    1. Gianetti A, Girolomoni G. Atopic dermatitis. In: Fritsch P, BurgdorfW, editors. EDF white book: skin diseases in Europe, 2nd edn. Berlin: ABW Wissenschaftsverlag GmbH. 2005. p. 69-71.

    2. Ellis C, Luger T. International Consensus Conference on Atopic Dermatitis II (ICCAD II): Chairman's introduction and overview. Br J Dermatol 2003;148(Suppl 63):1-2.

    3. Mohrenschlager M, Darsow U, Schnopp C, Ring J. Atopic eczema: what's new? J Eur Acad Dermatol Venereol 2006;20:503-13.

    4. Michail SK, Stolfi A, Johnson T, Onady GM. Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials. Ann Allergy Asthma Immunol 2008;101:508-16.

    5. Betsi GI, Papadavid E, Falagas ME. Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol 2008;9:93-103.

    6. GrĂ¼ber C, Wendt M, Sulser C. Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy. Allergy 2007;62:1270-6.

    7. Brouwer ML, Wolt-Plompen SA, Dubois AE, van der Heide S, Jansen DF, Hoijer MA, et al. No effects of probiotics in atopic dermatitis in infancy: a randomized placebo-controlled trial. Clin Exp Allergy 2006;36:899-906.

    8. Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2008; 122:788-94.

    9. Prescott SL, Dunstan JA, Hale J, Breckler L, Lehmann H, Weston S, et al. Clinical effects of probiotics are associated with increased interferon-gamma responses in very young children with atopic dermatitis. Clin Exp Allergy 2005;35:1557-64.

    10. Eyerich K, Huss-Marp J, Darsow U, Wollenberg A, Foerster S, Ring J, et al. Pollen grains induce a rapid and biphasic eczematous immune response in atopic eczema patients. Int Arch Allergy Immunol 2008;145:213-23.

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