Normal flora: diversity and functions

Article English OPEN
McFarland, Lynne V. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v12i4.8202

Recent research into the therapeutic use of living organisms has focused attention on the impact of various disruptive factors (antibiotics, surgery, immunosuppression) and their impact on the host’s normal flora. This review covers what is meant by ‘normal flora’, how the microecology differs by the niche in the body, type of diet, age and health status. In addition, the functions and tools used to investigate normal flora will be explored. The functions of the normal flora include digestion of substrates, production of vitamins, stimulation of cell maturation, stimulation of the immune system, aid in intestinal transit and colonization resistance. A variety of factors can disrupt the normal flora including age, diet, stress, illness and exposure to antibiotics. Research involving microecologic populations is difficult due to the challenge of unraveling the complex dynamics within a usually inaccessible niche, but progress is being made.
  • References (138)
    138 references, page 1 of 14

    1. Gordon R. The alarming history of medicine. New York: St. Martin's Press, 1993: 164.

    2. Savage DC. Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 1977; 31: 107 -33.

    3. Salminen S, Isolauri E, Onnela T. Gut ora in normal and disordered states. Chemotherapy 1995; 41: 5 - 15.

    4. Keane FE, Ison CA, Taylor-Robinson D. A longitudinal study of the vaginal ora over a menstrual cycle. Int J STD AIDS 1997; 8: 489 -94.

    5. Martin HL Jr, Richardson BA, Nyange PM, Lavreys L, Hillier SL, Chohan B, Mandaliya K, Ndinya-Achola JO, Bwayo J, Kreiss J. Vaginal lactobacilli, microbial ora, and risk of human immunode ciency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180: 1863 - 8.

    6. Marshall JC. Gastrointestinal ora and its alterations in critical illness. Curr Opin Clin Nutr Metab Care 1999; 2: 405 - 11.

    7. Priestley CJ, Jones BM, Dhar J, Goodwin L. What is normal vaginal ora? Genitourin Med 1997; 73: 23 - 8.

    8. Hooper LV, Bry L, Falk PG, Gordon JI. Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. BioEssays 1998; 20: 336 - 43.

    9. Hentges DJ. The anaerobic micro ora of the human body. Clin Infect Dis 1993; 16: S175 - 80.

    10. Hagiage M. La ora intestinale de l'e´quilibre au de´se´quilibre. Paris: Vigot, 1994: 25.

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