Production of a Broad Spectrum Antimicrobial Substance by Lactobacillus reuteri

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Axelsson, L. T. ; Chung, T. C. ; Dobrogosz, W. J. ; Lindgren, S. E. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v2i2.7449
  • Subject:
    mesheuropmc: food and beverages | bacteria

Lactobacillus reuteri resides in the gastrointestinal tract of humans, swine, poultry and other animals. Resting cells of this species convert glycerol into a potent, broad-spectrum antimicrobial substance termed reuterin. Reuterin is a low molecular weight, neutral, water soluble compound, capable of inhibiting growth of species representing all bacterial genera tested thus far, including: Escherichia, Salmonella, Shigella, Proteus, Pseudomonas, Clostridium and Staphylococcus. Also affected, but to a lesser degree, are lactic acid bacteria belonging to the genera Streptococcus, Pediococcus, Leuconostoc, and Lactobacillus. In this report we describe a method to screen lactobacilli for production of unique antimicrobial substances and the discovery of reuterin.Keywords: Lactobacillus reuteri: Antimicrobial substance; Reuterin; Broad-spectrum activity.
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