Subject: Microbiota | tagatose | Rubus glaucus | intestine absorption | questionnaire | Butyrate | Healthy subjects | defecation | in vitro study | lipid | D-tagatose | butyric acid | double blind procedure | controlled clinical trial | safety | parameter | Lactobacillus | gastrointestinal symptom | priority journal | female | human | placebo | clinical trial | normal human | fructose oligosaccharide | human experiment | incubation time | stomach absorption | Health | in vivo study | sucrose | prebiotic agent | article | Biomedical Research | Gastrointestinal health | short chain fatty acid | randomized controlled trial | colon flora | controlled study | Acacia acuminata | Colon | crossover procedure | male
mesheuropmc: fluids and secretions | digestive, oral, and skin physiology
D-Tagatose is partly absorbed in the stomach and small intestine. Most of it is fermented by the large intestinal microbiota. The effect of D-tagatose on the composition of the microbiota and production of short chain fatty acids (SCFAs) was studied in vivo and in vitro... View more
1. Levin GV, Zehner LR, Saunders JP, Beadle JR. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am J Clin Nutr. 1995;62:1161S / 8S.
2. Laerke HN, Jensen BB. D-tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs. J Nutr. 1999;129:1002 /9.
3. Normen L, Laerke HN, Jensen BB, Langkilde AM, Andersson H. Small-bowel absorption of D-tagatose and related effects on carbohydrate digestibility: an ileostomy study. Am J Clin Nutr. 2001;73:105 /10.
4. Bertelsen H, Andersen H, Tvede M. Fermentation of D-tagatose by human intestinal bacteria and dairy lactic acid bacteria. Microb Ecol Health Dis. 2000;13:87 /95.
5. Laerke HN, Jensen BB, Hojsgaard S. In vitro fermentation pattern of D-tagatose is affected by adaptation of the microbiota from the gastro-intestinal tract of pigs. J Nutr. 2000;130:1772 /9.
6. Young GP, Gibson RP. Butyrate and the colorectal cancer cell. In: Binder HJ, Cummings J, Soergel KH. editors. Short chain fatty acids. Dordrecht: Kluwer Academic; 1995. p. 148 /60.
7. Scheppach W, Bartram HP, Richter F. Role of short-chain fatty acids in the prevention of colorectal cancer. Eur J Cancer. 1995;31:1077 /80.
8. Minekus M, Smeets-Peeters MJE, Bernalier A, Marol-Bonnin S, Havenaar R, Marteau P, et al. A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products. Appl Microb Biotechnol. 1999;53:108 / 14.
9. Venema K, Van Nuenen HMC, Smeets-Peeters MJE, Minekus M, Havenaar R. TNO's in vitro large intestinal model: an excellent screening tool for functional food and pharmaceutical research. Erna¨hrung/Nutrition. 2000;24:558 /64.
10. Declaration of Helsinki. Republic of South Africa: Somerset West, 1996.