Abstracts from the Second International Meeting of ISEV 2013 Boston, USA, April 17th-20th, 2013

Article English OPEN
supplement, Complete (2013)
  • Publisher: Journal of Extracellular Vesicles
  • Journal: Journal of Extracellular Vesicles
  • References (13)
    13 references, page 1 of 2

    1. Karlsson, et al. J Immunol Methods 1993;166:75 84. 1. Wood et al. Nat Biotechnol 2011. 2. Wood et al. Nat Protoc 2012.

    The anaphylatoxin C5a, a potent complement activation product,

    the cleavage of C5. Methods: Whole blood (anticoagulated with the

    specific thrombin inhibitor lepirudin) from healthy donors (n=7),

    exposed to 108 Nm/mL9eculizumab (Soliris†)100 mg/mL for 4 h

    (378C) was sequentially centrifuged 2 times (2000 g,15 min, RT).

    centrifugation 3 times (17000 g, 30 min, RT). Pelleted MPs were

    blood exposed to 108 Nm/mL gave a significant shortening of

    the time to clot formation: 303 s999 s (mean9SD) compared with

    MPs isolated from unexposed blood: 1015 s9210 s (p=0.001).

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