Models to Study Colonisation and Colonisation Resistance

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Boreau, H. ; Hartmann, L. ; Karjalainen, T. ; Rowland, I. ; Wilkinson, M. H. F. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v12i2.8111

This review describes various in vivo animal models (humans; conventional animals administered antimicrobial agents and animals species used; gnotobiotic and germ-free animals), in vitro models (luminal and mucosal), and in silico and mathematicalmodels which have been developed to study colonisation and colonisation resistance and effects of gut flora on hosts. Where applicable, the advantages and disadvantages of each model are discussed.Keywords: colonisation, colonisation resistance, animal models, in vitro colonisation models, in silico and mathematical colonisation models.
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