Impaired fasting glucose and metabolic syndrome in an indigenous siberian population

Article English OPEN
Snodgrass, J. Josh ; Leonard, William R. ; Tarskala, Larissa A. ; Egorova, Aitalina G. ; Maharova, Natalia V. ; Pinigina, Irina A. ; Halyev, Simeon D. ; Matveeva, Niurguyana P. ; Romanova, Anna N. (2012)
  • Publisher: Co-Action Publishing
  • Journal: International Journal of Circumpolar Health (issn: 1797-237X, eissn: 1239-9736)
  • Related identifiers: doi: 10.3402/ijch.v69i1.17430
  • Subject: cardiovascular disease, diabetes, obesity, anthropometry, market integration, Russia

Objectives. This study investigated the lifestyle and anthropometric correlates of impaired fastingglucose and the presence of metabolic syndrome (MetS) among an Indigenous high-latitude herdingpopulation from north-eastern Siberia.Study Design. Cross-sectional study of Yakut (Sakha) adult volunteers.Methods. We collected health, lifestyle and anthropometric data among 166 Yakut adults (≥18years old; 101 females, 65 males) from the rural village of Tyungyulyu (62°N, 130°E; population2,500), Sakha Republic (Yakutia), Russia. Measurements of fasting glucose, triglycerides, HDLcholesterol, blood pressure and waist circumference were used to document the presence of MetSbased on the updated Adult Treatment Panel (ATP) III definition.Results. Metabolic syndrome was relatively uncommon among study participants, with only 10%of participants classified as having MetS, including 8% of females and 12% of males. Elevatedblood pressure and low HDL cholesterol were the most common features of MetS in Yakut men andwomen, while elevated fasting glucose and high triglycerides were uncommon in both sexes. Relativelylow mean fasting glucose concentrations were documented among Yakut women (4.46±0.65mmol/L) and men (4.41±0.76 mmol/L); no participants were classified as diabetic.Conclusions. Fasting glucose and MetS are at relatively low levels in this population; however,rising rates of obesity are likely to lead to future increases in MetS and impaired fasting glucose inthis population. Further, increasing consumption of market foods, many high in refined sugars, islikely to contribute to an increased presence of impaired fasting glucose and MetS.(Int J Circumpolar Health 2010; 69(1):87–98)Keywords: cardiovascular disease, diabetes, obesity, anthropometry, market integration, Russia
  • References (48)
    48 references, page 1 of 5

    1. WHO (World Health Organization). Definition, diag - nosis and classification of diabetes mellitus and its complications. Geneva: World Health Organization; 1999.

    2. NCEP (National Cholesterol Education Program). Expert panel on the detection, evaluation and treatment of high blood cholesterol in adults: executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285 (19):2486-2497.

    3. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation 2005;112(17):2735-2752.

    4. Alberti KGMM, Zimmet P, Shaw J. Metabolic syndrome - a new world-wide definition: a consensus statement from the International Diabetes Federation. Diabet Med 2006;23(5):469-480.

    5. Reaven GM. Banting lecture 1988: role of insulin resistance in human disease. Diabetes 1988;37(12):1595- 1607.

    6. Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 1991;34(6): 416-422.

    7. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes and inflammation. Circulation 2005;111(11):1448-1454.

    8. Gami AS, Witt BJ, Howard DE, et al. Metabolic syndrome and risk of incident cardiovascular events: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007;49(4):403-414.

    9. Cameron AJ, Shaw JE, Zimmet PZ. The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am 2004;33(2):351-375.

    10. Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care 2004;27(10):2444-2449.

  • Metrics
    No metrics available
Share - Bookmark