From HIV Infection to AIDS: Changes in the Microbial Ecology of Skin and Nose
Bibel, D. J.
Conant, M. A.
Shinefield, H. R.
- Publisher: Microbial Ecology in Health and Disease
Microbial Ecology in Health and Disease
(issn: 1651-2235, eissn: 1651-2235)
To investigate the early events of opportunistic infection in AIDS, microorganisms inhabiting the cheek and groin skin and nasal vestibule of 19 male HIV-infected patients in various stages of illness were identified and quantified quarterly for 1 y. During the course of their infection, HIV-positive patients tended to decrease their carriage of microorganisms, by populations on the skin and by fewer species on all sites, especially the groin. Nasal carriage of Staphylococcus aureus was 56 per cent, compared to 22 per cent in healthy subjects. About 35 per cent of HIV-positive patients carried Candida albicans in the oral cavity, compared to 5 per cent in HIV-negative subjects. Enhancement of staphylococcal adherence to nasal and cutaneous cells in HIV-positive subjects was, in thigh cells, related to the severity of infection. The sequelae of HIV-infection seems to include hazardous alterations of the epithelial habitats of microorganisms.Keywords: AIDS; HIV; Staphylococcus aureus; Candida albicans; Skin flora.