Investigating subtypes of reward processing deficits as trait markers for depression

Article English OPEN
Frey, Anna-Lena ; Malinowska, Lucy ; Harley, Katherine ; Salhi, Louisa ; Iqbal, Somya ; Sharma, Sarika ; McCabe, Ciara (2015)
  • Publisher: Translational Developmental Psychiatry
  • Journal: Translational Developmental Psychiatry
  • Subject:
    mesheuropmc: behavior and behavior mechanisms | behavioral disciplines and activities | psychological phenomena and processes

Background: Anhedonia, the loss of pleasure in usually enjoyable activities, is a central feature of major depressive disorder (MDD). The aim of the present study was to examine whether young people at a familial risk of depression display signs of anticipatory, motivational or consummatory anhedonia, which would indicate that these deficits may be trait markers for MDD.Methods: The study was completed by 22 participants with a family history of depression (FH+) and 21 controls (HC). Anticipatory anhedonia was assessed by asking participants to rate their anticipated liking of pleasant and unpleasant foods which they imagined tasting when cued with images of the foods. Motivational anhedonia was measured by requiring participants to perform key presses to obtain pleasant chocolate taste rewards or to avoid unpleasant apple tastes. Additionally, physical consummatory anhedonia was examined by instructing participants to rate the pleasantness of the acquired tastes. Moreover, social consummatory anhedonia was investigated by asking participants to make preference-based choices between neutral facial expressions, genuine smiles, and polite smiles.Results: It was found that the FH+ group’s anticipated liking of unpleasant foods was significantly lower than that of the control group. By contrast, no group differences in the pleasantness ratings of the actually experienced tastes or in the amount of performed key presses were observed. However, controls preferred genuine smiles over neutral expressions more often than they preferred polite smiles over neutral expressions, while this pattern was not seen in the FH+ group.Conclusion: These findings suggest that FH+ individuals demonstrate an altered anticipatory response to negative stimuli and show signs of social consummatory anhedonia, which may be trait markers for depression.Keywords: reward; aversion; behaviour; consummatory anhedonia; motivational anhedonia; social anhedonia; anticipatory anhedonia; trait marker; food; depression(Published: 14 August 2015)Citation: Translational Developmental Psychiatry 2015, 3: 27517 -
  • References (46)
    46 references, page 1 of 5

    1. Kessler RC, Chiu WT, Demler O, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 617 27.

    2. Murray CJL, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Geneva, Switzerland: World Health Organization; 1996.

    3. Rush J, Trivedi M, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. Am J Psychiatry 2006; 163: 1905 17.

    4. Maalouf FT, Brent D, Clark L, Tavitian L, McHughe RM, Sahakian BJ, et al. Neurocognitive impairment in adolescent major depressive disorder: state vs. trait illness markers. J Affect Disord 2011; 133: 625 32.

    5. Beardslee WR, Versage EM, Gladstone TR. Children of affectively ill parents: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 1998; 37: 1134 41.

    6. Hasler G, Drevets WC, Manji HK, Charney DS. Discovering endophenotypes for major depression. Neuropsychopharmacology 2004; 29: 1765 81.

    7. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-V, fifth ed. Washington, DC: American Psychiatric Association; 2013.

    8. Treadway MT, Zald DH. Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev 2011; 35: 537 55.

    9. Berridge KC. Food reward: brain substrates of wanting and liking. Neurosci Biobehav Rev 1996; 20: 1 25.

    10. Cousins MS, Atherton A, Turner L, Salamone JD. Nucleus accumbens dopamine depletions alter relative response allocation in a T-maze cost/benefit task. Behav Brain Res 1996; 74: 189 97.

  • Metrics
    No metrics available
Share - Bookmark