Hereditary angioedema presenting as irritable bowel syndrome: a case of early closure

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Benrajab, Karim M. ; Singh, Gurkeerat ; Obah, Eugene (2015)
  • Publisher: Journal of Community Hospital Internal Medicine Perspectives
  • Journal: Journal of Community Hospital Internal Medicine Perspectives, volume 5, issue 5 (eissn: 2000-9666)
  • Related identifiers: doi: 10.3402/jchimp.v%v.29114, doi: 10.3402/jchimp.v5.29114, pmc: PMC4612482
  • Subject: C4 | hereditary angioedema | C4; hereditary angioedema; IBS; abdominal pain; C1 esterase inhibitor | abdominal pain | Case Report | IBS | C1 esterase inhibitor

Abdominal pain is one of the most common reasons for outpatient and emergency department visits. We present one such case of early closure in a 32-year-old male with recurrent abdominal pain who was diagnosed with irritable bowel syndrome (IBS). Family history was suspicious for hereditary angioedema (HAE). The HAE workup came back positive, and the patient was started on prophylactic therapy, which led to an improvement in symptoms and quality of life. The purpose of this case is to create awareness among physicians to test for HAE in patients diagnosed with IBS who, based on their history or physical examination, have clinical suspicion for HAE.Keywords: C4; hereditary angioedema; IBS; abdominal pain; C1 esterase inhibitor(Published: 19 October 2015)Citation: Journal of Community Hospital Internal Medicine Perspectives 2015, 5: 29114 -
  • References (20)
    20 references, page 1 of 2

    1. Hungin AP, Whorwell PJ, Tack J, Mearin F. The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects. Aliment Pharmacol Ther 2003; 17: 643 50. Available from: pubmed/12641512

    2. Canavan C, West J, Card T. The epidemiology of irritable bowel syndrome. Clin Epidemiol 2014; 6: 71 80. Available from:

    3. Longhurst H, Cicardi M. Hereditary angio-oedema. Lancet 2012; 379: 474 81. Available from: http://www.ncbi.nlm.nih. gov/pubmed/22305226

    4. Nzeako UC, Frigas E, Tremaine WJ. Hereditary angioedema: a broad review for clinicians. Arch Intern Med 2001; 161: 2417 29. Available from:

    5. Osler W. Hereditary angioneurotic oedema. Am J Med Sci 1888; 95: 362 7.

    6. Donaldson VH, Evans RR. A biochemical abnormality in hereditary angioneurotic edema: absence of serum inhibitor of C' 1-esterase. Am J Med 1963; 35: 37 44. Available from:

    7. Cicardi M, Johnston DT. Hereditary and acquired complement component 1 esterase inhibitor deficiency: a review for the hematologist. Acta Haematol 2012; 127: 208 20. Available from:

    8. Ali MA, Borum ML. Hereditary angioedema: what the gastroenterologist needs to know. Clin Exp Gastroenterol 2014; 7: 435 45. doi: Available from:

    9. Cicardi M, Aberer W, Banerji A, Bas M, Bernstein JA, Bork K, et al. Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group. Allergy 2014; 69: 602 16. Available from:

    10. Bork K, Meng G, Staubach P, Hardt J. Hereditary angioedema: new findings concerning symptoms, affected organs, and course. Am J Med 2006; 119: 267 74. Available from: http://www.ncbi.

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