Bacterial Faecal Flora in Healthy Women of Different Ages

Article English OPEN
Minelli, E. Bertazzoni ; Benini, A. ; Beghini, A. M. ; Cerutti, R. ; Nardo, G. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v6i2.8091

The composition of the intestinal flora is the result of host physiology, microbial interaction and environmental influences. The possible relationship between faecal flora composition and hormonal modifications in healthy women of different ages was studied. Forty-four normal women were divided into the following groups according to age: group I, 2747 yr; group II, 50-55 yr, < 5 yr after menopause; group III, 56-78 yr, > 5 yr after menopause. The subjects received no pharmacological treatment. Samples were collected on the 8th and 23rd day of the cycle; two samples were obtained from each postmenopausal woman. Qualitative and quantitative determination of microorganisms was carried out using slightly modified standard methods. In fertile women (group I), the microflora composition was similar for samples collected on the 8th-10th day and during the premenstrual period (23rd day). In postmenopausal women (group III), an increase in fungi, clostridia and aerobic lactobacilli mean concentrations were observed. Escherichia coli mean levels increased and Enterobacteriaceae such as Enterobacter cloacae and Citrobacter freundii were present in 80 per cent of subjects studied. The length of menopause was found to have only a slight influence on flora: the behaviour of the microflora composition in menopausal women in group II may be considered intermediate between groups I and III. This preliminary study demonstrates that there are fluctuations in the composition of the faecal flora in healthy women. The differences observed between premenopausal and postmenopausal women may be a consequence of modifications of the steroid sex hormone pattern.Keywords - Intestinal flora; Age; Premenopausal women; Postmenopausal women; Menopause.
  • References (36)
    36 references, page 1 of 4

    1 . Abrams GD, Bishop JE. (1966). Effect of the normal microbial flora on the resistance of the small intestine to infection. Journal of Bacteriology 92,1604-1 608.

    2. Barza M, Giuliano M, Jacobus NJ, Gorbach SL. (1987). Effect of broad-spectrum parenteral antibiotics on 'colonization resistance' of intestinal microflora of humans. Anfimicrobial Agents and Chemotherapy 31,723-727.

    3. Bertazzoni Minelli E, Nardo G, Pavanato G, Cerutti R, Benoni G. (1986). Composizione della flora batterica nella sindrome premestruale: nota preliminare. Annuli Istituto Superiore Sanitu 22, 915-918.

    4. Bertazzoni Minelli E, Beghini AM, Vesentini S, Marchiori L, Mortani E, Nardo G , Cerutti R. (1990). Intestinal microflora as an alternative metabolic source of oestrogens in women with uterine leiomyoma and breast cancer. Annals of the New York Academy of Sciences 595,413-479.

    5. Bornside GH. (1978). Stability of human faecal flora. American Journal of Clinical Nutrition 31, S 141- 144.

    6. Deslypere DP, Verbdonck L, Vermeulen A. (1985). Effect time: a steroid reservoir and site of steroid metabolism. Journal of Clinical Endocrinology and Metabolism 61,564-570.

    7. Drasar BS, Hill MJ (eds). (1974). Human Intestinal Flora, 1st edn. Academic Press, London, pp. 103- 149.

    8. Dobkin JF, Saha JR, Butler VP, Neu HC, Lindenbaum J. (1982). Inactivation of digoxin by Eubacterium lentum, an anaerobe of the human gut flora. Clinical Research 30,55 1A.

    9. Dubos R, Schaedler RW, Costello R. (1963). Composition, alteration and effects of intestinal flora. Federation Proceedings 22,1322-1 329.

    10. Edlund C, Lidbeck A, Kager L, Nord CE. (1987). Comparative effects of enoxacin and norfloxacin on human colonic flora. Antimicrobial Agents and Chemotherapy 31,1846-1848.

  • Metrics
    No metrics available
Share - Bookmark