Human papillomavirus and cervical dysplasia in Nunavut: prelude to a screening strategy

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Healey, Sylvia M. ; Aronson, Kristan J. ; Mao, Yang ; Franco, Eduardo L. (2004)
  • Publisher: Co-Action Publishing
  • Journal: International Journal of Circumpolar Health (issn: 1797-237X, eissn: 1239-9736)
  • Related identifiers: doi: 10.3402/ijch.v63i0.17901
  • Subject: papillomavirus, Papanicolaou test, cervix neoplasms, screening, Inuit
    mesheuropmc: virus diseases | female genital diseases and pregnancy complications

Objectives. To determine the prevalence of oncogenic human papillomavirus’ (HPV) in Nunavut and to assess the association between HPV and squamous intraepithelial lesions (SIL) as a prelude to planning a better screening strategy. Study Design. A cross-sectional study was conducted on the Pap-screened populations in 19 communities in Nunavut, Canada. SIL was determined using Liquid-based cytology, and HPV testing was done using the Hybrid Capture II assay. Results. Prevalence of oncogenic HPVs in 1,290 women ages 13-79 was 26% and of Cervical Dysplasia was 7.2%. Over 90% of women with SIL had positive HPV tests. Over 75% of women who were HPV positive but SIL negative were under 30 years of age. Conclusion. Consideration should be given to using liquid-based cytology for Pap testing. Also consider concurrent HPV testing in those over 30 years old and reflex testing of HPV in those under 30 years old with a positive HPV test.Keywords: papillomavirus, Papanicolaou test, cervix neoplasms, screening, Inuit
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