Animal Models to Assess the Pathogenicity of Genetically Modified Microorganisms for Humans
Hentges, D. J.
Petschow, B. W.
Dougherty, S. H.
Marsh, W. W.
- Publisher: Microbial Ecology in Health and Disease
Microbial Ecology in Health and Disease
(issn: 1651-2235, eissn: 1651-2235)
Two animal models are proposed to assess the colonising capacities and other virulence factors of genetically modified enteric microorganisms for humans. One is the streptomycin treated mouse which is exceedingly susceptible to colonisation with enteric pathogens. The other is the human intestinal microbiota associated mouse which, in ecological studies, responded in a manner similar to human infants to variations in diet. The latter model is recommended because of differences between human and animal microbiotas and the important role of the microbiota in resisting colonisation with pathogenic microorganisms.Keywords - Animal models, Pathogenicity, Genetically modified microorganisms.