Putative Virulence Factors of Candida Species Colonizing Respiratory Tracts of Patients
Shehabi, Asem A.
Nazzal, Shatha A.
- Publisher: Microbial Ecology in Health and Disease
Microbial Ecology in Health and Disease
(issn: 1651-2235, eissn: 1651-2235)
The objective of this research was to investigate the patterns of Candida species colonizing respiratory tracts of hospitalized patients and their production of putative virulence factors in vitro. One hundred and twenty-nine Candida isolates were collected from respiratory tract specimens of adult Jordanian patients admitted to Jordan University Hospital (JUH) during the period 1999/2001. The patterns of colonization were as follows. C. albicans accounted for (67%) of the isolates, followed by non-C. albicans isolates (33%), including C. krusei (12%), C. tropicalis (11%), C. glabrata (6%) and other Candida spp. (4%). No significant differences were determined between the Candida isolates as regards their secretion in vitro of variable amounts of putative virulence factors - aspartyl proteinase, phospholipase and haemolysin (p>0.05). However, the mean production of proteinase using qualitative measurements is clearly more observed in C. albicans isolates colonizing the respiratory tract. The study concludes that putative virulence factors alone are not responsible for the colonization potential of Candida species. Key words: Candida species, virulence factors, human respiratory tract, Jordan.