The contribution of twin studies to the understanding of the aetiology of asthma and atopic diseases

Article English OPEN
Thomsen, Simon F. (2015)
  • Publisher: Co-Action Publishing
  • Journal: European Clinical Respiratory Journal (issn: 2001-8525, vol: 2)
  • Related identifiers: doi: 10.3402/ecrj.v2i0.27803, doi: 10.3402/ecrj.v2.27803, pmc: PMC4653279
  • Subject: genetic | epidemiology | Review Article | environment | atopic diseases | twin study | atopic dermatitis | Asthma | hay fever
    mesheuropmc: body regions

The prevalence of asthma and other atopic diseases has increased markedly during the past decades and the reasons for this are not fully understood. Asthma is still increasing in many parts of the world, notably in developing countries, and this emphasizes the importance of continuing research aimed at studying the aetiological factors of the disease and the causes of its increase in prevalence. Twin studies enable investigations into the genetic and environmental causes of individual variation in multifactorial diseases such as asthma. Thorough insight into these causes is important as this will ultimately guide the development of preventive strategies and targeted therapies. This review explores the contribution of twin studies to the understanding of the aetiology of asthma and atopic diseases.Keywords: Asthma; atopic dermatitis; atopic diseases; environment; epidemiology; genetic; hay fever; twin study(Published: 11 September 2015)Citation: European Clinical Respiratory Journal 2015, 2: 27803 - http://dx.doi.org/10.3402/ecrj.v2.27803
  • References (88)
    88 references, page 1 of 9

    1. Anandan C, Nurmatov U, van Schayck OC, Sheikh A. Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy. 2010; 65: 152 67.

    2. Thomsen SF. Exploring the origins of asthma: lessons from twin studies. Eur Clin Respir J. 2014; 1: 25535, doi: http://dx.doi.org/ 10.3402/ecrj.v1.25535

    3. Duffy DL, Martin NG, Battistutta D, Hopper JL, Mathews JD. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis. 1990; 142: 1351 8.

    4. Nieminen MM, Kaprio J, Koskenvuo M. A population-based study of bronchial asthma in adult twin pairs. Chest. 1991; 100: 70 5.

    5. Lichtenstein P, Svartengren M. Genes, environments, and sex: factors of importance in atopic diseases in 7 9-year-old Swedish twins. Allergy. 1997; 52: 1079 86.

    6. Harris JR, Magnus P, Samuelsen SO, Tambs K. No evidence for effects of family environment on asthma. A retrospective study of Norwegian twins. Am J Respir Crit Care Med. 1997; 156: 43 9.

    7. Laitinen T, Rasanen M, Kaprio J. Importance of genetic factors in adolescent asthma: a population-based twin-family study. Am J Respir Crit Care Med. 1998; 157: 1073 8.

    8. Skadhauge LR, Christensen K, Kyvik KO, Sigsgaard T. Genetic and environmental influence on asthma: a population-based study of 11,688 Danish twin pairs. Eur Respir J. 1999; 13: 8 14.

    9. Koeppen-Schomerus G, Stevenson J, Plomin R. Genes and environment in asthma: a study of 4 year old twins. Arch Dis Child. 2001; 85: 398 400.

    10. Nystad W, Roysamb E, Magnus P, Tambs K, Harris JR. A comparison of genetic and environmental variance structures for asthma, hay fever and eczema with symptoms of the same diseases: a study of Norwegian twins. Int J Epidemiol. 2005; 34: 1302 9.

  • Metrics
    No metrics available
Share - Bookmark