Effect of Intraparturn Chemoprophylaxis and Mode of Delivery on Neonatal Gut Colonisation
- Publisher: Microbial Ecology in Health and Disease
Microbial Ecology in Health and Disease
(issn: 1651-2235, eissn: 1651-2235)
mesheuropmc: reproductive and urinary physiology | female genital diseases and pregnancy complications
This study was undertaken to investigate the influence of intrapartum chemotherapy on gut colonisation of healthy full-term neonates delivered vaginally or by caesarean section. The study included 73 pregnant women and their 73 newborns. The mothers (n = 37) in the treatment group received intrapartum ampicillin before delivery and the mothers (n= 36) in the other group remained untreated. In the newborns, vaginal delivery leads to increased colonisation by Bacteroides (P < 0.000 1) and Lactobacillus spp. (P = 0.0020). Intrapartum administration of ampicillin delayed colonisation by Lactobacillus spp. (P = 0.0012) after vaginal delivery. The results of this study show that even a single-dose intrapartum administration of ampicillin exposes the neonate to colonisation disturbances of Lactobacillus spp., just as does caesarean section.Keywords - Neonate, newborn; Colonisation; Intrapartum; Chemotherapy.