Effect of Intraparturn Chemoprophylaxis and Mode of Delivery on Neonatal Gut Colonisation

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Ahtonen, P. ; Peltonen, R. ; Lehtonen, O-P. ; Kero, P. ; Erkkola, R. ; Eerola, E. (2011)
  • Publisher: Microbial Ecology in Health and Disease
  • Journal: Microbial Ecology in Health and Disease (issn: 1651-2235, eissn: 1651-2235)
  • Related identifiers: doi: 10.3402/mehd.v6i2.8093
  • Subject:
    mesheuropmc: reproductive and urinary physiology | female genital diseases and pregnancy complications

This study was undertaken to investigate the influence of intrapartum chemotherapy on gut colonisation of healthy full-term neonates delivered vaginally or by caesarean section. The study included 73 pregnant women and their 73 newborns. The mothers (n = 37) in the treatment group received intrapartum ampicillin before delivery and the mothers (n= 36) in the other group remained untreated. In the newborns, vaginal delivery leads to increased colonisation by Bacteroides (P < 0.000 1) and Lactobacillus spp. (P = 0.0020). Intrapartum administration of ampicillin delayed colonisation by Lactobacillus spp. (P = 0.0012) after vaginal delivery. The results of this study show that even a single-dose intrapartum administration of ampicillin exposes the neonate to colonisation disturbances of Lactobacillus spp., just as does caesarean section.Keywords - Neonate, newborn; Colonisation; Intrapartum; Chemotherapy.
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